Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-8-19
pubmed:abstractText
Prior studies report slightly lower prostate-specific antigen (PSA) levels among obese men. To understand this effect, we investigated the association between PSA and blood HbA1c, C-peptide, leptin and adiponectin levels in African-American (AA) (n=121) and Caucasian (CA) (n=121) men. Among AA men, PSA levels decreased with increasing C-peptide levels (PSA=0.99, 0.93, 0.75 and 0.53 ng ml(-1) across quartiles of C-peptide, respectively; P(trend)=0.005). Among CA men, PSA levels decreased with increasing HbA1c (PSA=0.84, 0.73, 0.77 and 0.45 ng ml(-1) across quartiles of HbA1c, respectively; P(trend)=0.005). This may suggest that metabolic disturbances related to metabolic syndrome or diabetes affect the ability to detect early-stage prostate cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1476-5608
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
264-9
pubmed:meshHeading
pubmed-meshheading:17938644-Adiponectin, pubmed-meshheading:17938644-Adult, pubmed-meshheading:17938644-African Americans, pubmed-meshheading:17938644-Aged, pubmed-meshheading:17938644-Body Mass Index, pubmed-meshheading:17938644-C-Peptide, pubmed-meshheading:17938644-Cohort Studies, pubmed-meshheading:17938644-Diabetes Complications, pubmed-meshheading:17938644-Early Diagnosis, pubmed-meshheading:17938644-European Continental Ancestry Group, pubmed-meshheading:17938644-Hemoglobin A, Glycosylated, pubmed-meshheading:17938644-Humans, pubmed-meshheading:17938644-Leptin, pubmed-meshheading:17938644-Male, pubmed-meshheading:17938644-Metabolic Syndrome X, pubmed-meshheading:17938644-Middle Aged, pubmed-meshheading:17938644-Prostate-Specific Antigen, pubmed-meshheading:17938644-Prostatic Neoplasms
pubmed:year
2008
pubmed:articleTitle
Association between prostate-specific antigen and leptin, adiponectin, HbA1c or C-peptide among African-American and Caucasian men.
pubmed:affiliation
Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA. jay.fowke@vanderbilt.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural