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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0034693,
umls-concept:C0185117,
umls-concept:C0458003,
umls-concept:C0581621,
umls-concept:C0678723,
umls-concept:C0851285,
umls-concept:C0900627,
umls-concept:C1333226,
umls-concept:C1705335,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2008-1-18
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pubmed:abstractText |
Postsynaptic density (PSD)-95 is originally isolated from glutamatergic synapse where it serves as a physical tether to allow neuronal nitric oxide synthase (nNOS) signaling by N-methyl-D-aspartate receptor (NMDAR) activity. Considering the physiological importance of glutamate receptor and nitric oxide (NO) during development, we examined the spatiotemporal expression of PSD-95 and nNOS in the lumbar spinal cord at a postnatal stage. Temporally, both gene and protein levels of them gradually increased with age after birth, peaked at the postnatal day 14 (P14), and then decreased to an adult level. In addition, the enhanced coimmunoprecipitations between PSD-95 and nNOS were detected in developing spinal cord. Spatially, PSD-95 staining codistributed with nNOS in NeuN-positive motor neurons and sensory neurons at P14. These findings indicate that PSD-95 and nNOS might collectively participate in spinal cord development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0197-0186
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
495-501
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pubmed:meshHeading |
pubmed-meshheading:17904695-Aging,
pubmed-meshheading:17904695-Animals,
pubmed-meshheading:17904695-Animals, Newborn,
pubmed-meshheading:17904695-Cell Differentiation,
pubmed-meshheading:17904695-Fluorescent Antibody Technique,
pubmed-meshheading:17904695-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17904695-Lumbar Vertebrae,
pubmed-meshheading:17904695-Lumbosacral Region,
pubmed-meshheading:17904695-Male,
pubmed-meshheading:17904695-Membrane Proteins,
pubmed-meshheading:17904695-Motor Neurons,
pubmed-meshheading:17904695-Nerve Tissue Proteins,
pubmed-meshheading:17904695-Neurons,
pubmed-meshheading:17904695-Neurons, Afferent,
pubmed-meshheading:17904695-Nitric Oxide,
pubmed-meshheading:17904695-Nitric Oxide Synthase Type I,
pubmed-meshheading:17904695-Nuclear Proteins,
pubmed-meshheading:17904695-Rats,
pubmed-meshheading:17904695-Rats, Sprague-Dawley,
pubmed-meshheading:17904695-Spinal Cord,
pubmed-meshheading:17904695-Synapses,
pubmed-meshheading:17904695-Synaptic Membranes,
pubmed-meshheading:17904695-Synaptic Transmission
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pubmed:year |
2008
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pubmed:articleTitle |
Developmental regulation of PSD-95 and nNOS expression in lumbar spinal cord of rats.
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pubmed:affiliation |
The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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