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pubmed-article:17729161pubmed:abstractTextRemodeling of extracellular matrix (ECM) after lung damage depends on collagen degrading Matrix-Metallo-Proteinases (MMP) and their endogenous inhibitors (Tissue-Inhibitors of Metallo-Proteinases, TIMP). Transforming growth factor (TGF)-beta1 has been implicated in the pathogenesis of radiation-induced lung fibrosis upon its effects on fibroblast proliferation and collagen synthesis. Lung cancer patients have often elevated TGF-beta1 plasma levels as a result of increased TGF-beta1 expression in their tumours. On this background, we investigated the effect of irradiation on the MMP/TIMP system in the lung tissue of normal and transgenic TGF-beta1 mice, in which TGF-beta1 is overexpressed in the liver resulting in high TGF-beta1 plasma levels.lld:pubmed
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pubmed-article:17729161pubmed:articleTitleMatrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury.lld:pubmed
pubmed-article:17729161pubmed:affiliationDepartment of Radiotherapy and Radiooncology, Saarland University, Homburg/Saar, Germany.lld:pubmed
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