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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-8-30
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pubmed:abstractText |
Remodeling of extracellular matrix (ECM) after lung damage depends on collagen degrading Matrix-Metallo-Proteinases (MMP) and their endogenous inhibitors (Tissue-Inhibitors of Metallo-Proteinases, TIMP). Transforming growth factor (TGF)-beta1 has been implicated in the pathogenesis of radiation-induced lung fibrosis upon its effects on fibroblast proliferation and collagen synthesis. Lung cancer patients have often elevated TGF-beta1 plasma levels as a result of increased TGF-beta1 expression in their tumours. On this background, we investigated the effect of irradiation on the MMP/TIMP system in the lung tissue of normal and transgenic TGF-beta1 mice, in which TGF-beta1 is overexpressed in the liver resulting in high TGF-beta1 plasma levels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0955-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
665-76
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pubmed:meshHeading |
pubmed-meshheading:17729161-Animals,
pubmed-meshheading:17729161-Cell Proliferation,
pubmed-meshheading:17729161-Collagen,
pubmed-meshheading:17729161-Extracellular Matrix,
pubmed-meshheading:17729161-Fibroblasts,
pubmed-meshheading:17729161-Gene Expression Regulation,
pubmed-meshheading:17729161-Immunohistochemistry,
pubmed-meshheading:17729161-Lung Diseases,
pubmed-meshheading:17729161-Matrix Metalloproteinase 2,
pubmed-meshheading:17729161-Matrix Metalloproteinase 9,
pubmed-meshheading:17729161-Matrix Metalloproteinases,
pubmed-meshheading:17729161-Mice,
pubmed-meshheading:17729161-Mice, Inbred C57BL,
pubmed-meshheading:17729161-Mice, Transgenic,
pubmed-meshheading:17729161-Pulmonary Fibrosis,
pubmed-meshheading:17729161-Radiation Injuries, Experimental,
pubmed-meshheading:17729161-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:17729161-Tissue Inhibitor of Metalloproteinases,
pubmed-meshheading:17729161-Transforming Growth Factor beta1
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pubmed:year |
2007
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pubmed:articleTitle |
Matrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury.
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pubmed:affiliation |
Department of Radiotherapy and Radiooncology, Saarland University, Homburg/Saar, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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