Source:http://linkedlifedata.com/resource/pubmed/id/17697970
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2007-8-16
|
| pubmed:abstractText |
We retrospectively analyzed results of unrelated cord blood transplantation (UCBT) in 93 Fanconi anemia (FA) patients. Median age at transplantation was 8.6 years (1-45). The units transplanted were HLA-A, -B, or -DRB1 identical in 12 cases, 1 HLA mismatch in 35 cases, and 2 or 3 HLA differences in 45 cases. The median number of nucleated cells (NC) and CD34+ cells infused of recipient weight was 4.9x10(7)/kg and 1.9x10(5)/kg, respectively. Participating centers selected the preparative regimen of their choice, in 57 patients (61%), it included Fludarabine. Graft-versus-host disease (GVHD) prophylaxis consisted mostly of cyclosporine with prednisone. Cumulative incidence (CI) of neutrophil recovery was 60+/-5% at day +60. In multivariate analysis, Fludarabine containing regimen and NC infused>or=4.9x10(7)/kg were associated with higher probability of recovery. CI of grade II-IV acute and of chronic GVHD (aGVHD, cGVHD) was 32%+/-5% and 16%+/-4%, respectively. Overall survival (OS) was 40%+/-5%. In multivariate analysis, factors associated with favorable outcome were use of Fludarabine in the conditioning regimen, number of NC infused>or=4.9x10(7)/kg, and negative cytomegalovirus (CMV) serology in the recipient. In conclusion, factors easily modifiable such as donor selection and a Fludarabine-containing regimen can considerably improve survival in FA patients given a UCBT. These data are the basis for designing prospective protocols.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1083-8791
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| pubmed:author |
pubmed-author:BieringsMarcM,
pubmed-author:BittencourtMarcoM,
pubmed-author:BonfimCarmemC,
pubmed-author:ChampagneMartin AMA,
pubmed-author:DarbyshirePhilipP,
pubmed-author:Eurocord-Netcord and EBMT,
pubmed-author:FernandezManuél-NicolasMN,
pubmed-author:GluckmanElianeE,
pubmed-author:HarrisRichard ERE,
pubmed-author:IonescuIrinaI,
pubmed-author:KurtzbergJoanneJ,
pubmed-author:LocatelliFrancoF,
pubmed-author:PasquiniRicardoR,
pubmed-author:RochaVandersonV,
pubmed-author:WagnerJohnJ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1073-82
|
| pubmed:meshHeading |
pubmed-meshheading:17697970-Adolescent,
pubmed-meshheading:17697970-Adult,
pubmed-meshheading:17697970-Child,
pubmed-meshheading:17697970-Child, Preschool,
pubmed-meshheading:17697970-Cord Blood Stem Cell Transplantation,
pubmed-meshheading:17697970-Fanconi Anemia,
pubmed-meshheading:17697970-Female,
pubmed-meshheading:17697970-Graft Survival,
pubmed-meshheading:17697970-Histocompatibility Testing,
pubmed-meshheading:17697970-Humans,
pubmed-meshheading:17697970-Infant,
pubmed-meshheading:17697970-Male,
pubmed-meshheading:17697970-Middle Aged,
pubmed-meshheading:17697970-Retrospective Studies,
pubmed-meshheading:17697970-Risk Factors,
pubmed-meshheading:17697970-Survival Analysis,
pubmed-meshheading:17697970-Transplantation Conditioning,
pubmed-meshheading:17697970-Vidarabine
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Results of unrelated cord blood transplant in fanconi anemia patients: risk factor analysis for engraftment and survival.
|
| pubmed:affiliation |
Hôpital Saint Louis AP/HP, University of Paris VII, IUH, Paris, France. eliane.gluckman@sls.aphp.fr
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|