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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2007-7-3
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pubmed:abstractText |
Prostate cancer is a leading cause of cancer death among the aging male population but the mechanism underlying this association is unclear. Aberrant methylation of promoter CpG islands is associated with silencing of genes and age-dependent methylation of several genes has been proposed as a risk factor for sporadic cancer. We examined the extent of gene methylation in pathologically normal human prostate as a function of age.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3796-802
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17606710-Adolescent,
pubmed-meshheading:17606710-Adult,
pubmed-meshheading:17606710-Aged,
pubmed-meshheading:17606710-Aging,
pubmed-meshheading:17606710-CpG Islands,
pubmed-meshheading:17606710-DNA Methylation,
pubmed-meshheading:17606710-DNA Primers,
pubmed-meshheading:17606710-Gene Expression Regulation,
pubmed-meshheading:17606710-Humans,
pubmed-meshheading:17606710-Male,
pubmed-meshheading:17606710-Middle Aged,
pubmed-meshheading:17606710-Prostate,
pubmed-meshheading:17606710-Prostatic Neoplasms,
pubmed-meshheading:17606710-Regression Analysis,
pubmed-meshheading:17606710-Sequence Analysis, DNA
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pubmed:year |
2007
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pubmed:articleTitle |
Age-related DNA methylation changes in normal human prostate tissues.
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pubmed:affiliation |
Department of Pathology, Baylor College of Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. bernardk@bcm.tmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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