Linked Life Data

17582128

Source:http://linkedlifedata.com/resource/pubmed/id/17582128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-6-21
pubmed:databankReference
pubmed:abstractText
The present experiment was undertaken to determine the effects of dietary supplements of folic acid and vitamin B12 given from 3 wk before to 8 wk after calving on lactational performance and metabolism of 24 multiparous Holstein cows assigned to 6 blocks of 4 cows each according to their previous milk production. Supplementary folic acid at 0 or 2.6 g/d and vitamin B12 at 0 or 0.5 g/d were used in a 2 x 2 factorial arrangement. Supplementary folic acid increased milk production from 38.0 +/- 0.9 to 41.4 +/- 1.0 kg/d and milk crude protein yield from 1.17 +/- 0.02 to 1.25 +/- 0.03 kg/d. It also increased plasma Gly, Ser, Thr, and total sulfur AA, decreased Asp, and tended to increase plasma Met. Supplementary B12 decreased milk urea N, plasma Ile, and Leu and tended to decrease Val but increased homocysteine, Cys, and total sulfur AA. Liver concentration of phospholipids was higher in cows fed supplementary B12. Plasma and liver concentrations of folates and B12 were increased by their respective supplements, but the increase in plasma folates and plasma and liver B12 was smaller for cows fed the 2 vitamins together. In cows fed folic acid supplements, supplementary B12 increased plasma glucose and alanine, tended to decrease plasma biotin, and decreased Km of the methylmalonyl-coenzyme A mutase in hepatic tissues following addition of deoxyadenosylcobalamin, whereas it had no effect when cows were not fed folic acid supplements. There was no treatment effect on plasma nonesterified fatty acids as well as specific activity and gene expression of Met synthase and methylmalonyl-coenzyme A mutase in the liver. Ingestion of folic acid supplements by cows fed no supplementary B12 increased total lipid and triacylglycerols in liver, whereas these supplements had no effect in cows supplemented with B12. The increases in milk and milk protein yields due to folic acid supplements did not seem to be dependent on the vitamin B12 supply. However, when vitamin B12 was given in combination with folic acid, utilization of the 2 vitamins seems to be increased, probably more so in extrahepatic tissues. Metabolic efficiency seems also to be improved as suggested by similar lactational performance and dry matter intake for cows fed supplementary folic acid but increased plasma glucose and decreased hepatic lipids in cows fed folic acid and vitamin B12 together.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1525-3198
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3442-55
pubmed:meshHeading
pubmed-meshheading:17582128-5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase, pubmed-meshheading:17582128-Animal Feed, pubmed-meshheading:17582128-Animals, pubmed-meshheading:17582128-Cattle, pubmed-meshheading:17582128-Diet, pubmed-meshheading:17582128-Dietary Supplements, pubmed-meshheading:17582128-Female, pubmed-meshheading:17582128-Folic Acid, pubmed-meshheading:17582128-Gene Expression, pubmed-meshheading:17582128-Lactation, pubmed-meshheading:17582128-Liver, pubmed-meshheading:17582128-Methylmalonyl-CoA Mutase, pubmed-meshheading:17582128-Milk, pubmed-meshheading:17582128-Molecular Sequence Data, pubmed-meshheading:17582128-Pregnancy, pubmed-meshheading:17582128-RNA, Messenger, pubmed-meshheading:17582128-Random Allocation, pubmed-meshheading:17582128-Time Factors, pubmed-meshheading:17582128-Vitamin B 12
pubmed:year
2007
pubmed:articleTitle
Effects of dietary supplements of folic acid and vitamin B12 on metabolism of dairy cows in early lactation.
pubmed:affiliation
Agriculture et Agroalimentaire Canada, Centre de recherche et développement sur le bovin laitier et le porc, Sherbrooke, Québec, J1M 1Z3 Canada.
pubmed:publicationType
Journal Article, Comparative Study