Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-6-13
pubmed:abstractText
The presence of functional 5-HT4 receptors in human and its involvement in neonatal lupus erythematosus (NLE) have prompted us to study the receptor expression and role during embryogenesis. Earlier we managed to demonstrate that female BALB/c mice immunized against the second extracellular loop (SEL) of the 5-HT4 receptor gave birth to pups with heart block. To explain this phenomenon we investigated the expression of 5-HT4 receptors during mouse embryogenesis. At the same time we looked whether the consequence of 5-HT4 receptor immunomodulation observed earlier is in relation to receptor expression. We studied the expression of 5-HT4 receptor at the mRNA level and its two isoforms 5-HT4(a) and 5-HT4(d) at the protein level in embryos from BALB/c mice, at 8th, 12th, 18th gestation days (GD) and 1 day post natal (DPN). Simultaneously the receptor activity was inhibited by rising antibodies, in female mice against SEL of the receptor. The mice were mated and embryos were collected at 8th, 12th, 18th GD and 1 DPN.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-10220570, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-10449982, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-10646498, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-10679442, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-10683202, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-11069058, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-11173928, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-11180122, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-11181010, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-11406291, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-11728882, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-12469868, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-12540230, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-12888181, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-1412065, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-14556458, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-14579092, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-14965243, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-15118808, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-15896782, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-16009533, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-2186943, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-7638165, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-8367830, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-8400618, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-8430902, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-8466185, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-8506248, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-8673925, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-8946946, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-9006717, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-9165122, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-9603189, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-9626848, http://linkedlifedata.com/resource/pubmed/commentcorrection/17445258-9796780
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1471-213X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
34
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Immunomodulation by maternal autoantibodies of the fetal serotoninergic 5-HT4 receptor and its consequences in early BALB/c mouse embryonic development.
pubmed:affiliation
CNRS UPR 9021 Immunologie et Chimie Thérapeutiques Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France. kamelrehab@yahoo.com <kamelrehab@yahoo.com>
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't