Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-3-26
pubmed:abstractText
AMD3100 inhibits the interaction between SDF-1 and CXCR4, and rapidly mobilizes hematopoietic progenitors for clinical transplantation. However, the repopulating function of human cells mobilized with AMD3100 has not been characterized in comparison to cells mobilized with granulocyte-colony stimulating factor (G-CSF) in the same donor. Therefore, healthy donors were leukapheresed 4 hours after injection with AMD3100; after 10 days of drug clearance the same donor was mobilized with G-CSF, allowing a paired comparison of repopulation by mobilized cells. Transplantation of mononuclear cells (MNC) or purified CD34(+) cells was compared at limiting dilution into NOD/SCID mice. Human AMD3100-mobilized MNC possessed enhanced repopulating frequency in comparison to G-CSF-mobilized MNC from paired donors, and purified CD34(+) progenitors were at least as efficient as the G-CSF mobilized cells. The frequencies of NOD/SCID repopulating cells (SRC) were 1 SRC in 8.7 x 10(6) AMD3100-mobilized MNC compared to 1 SRC in 29.0 x 10(6) G-CSF-mobilized MNC, and 1 SRC in 1.2 x 10(5) AMD3100-mobilized CD34(+) cells compared to 1 SRC in 1.8 x 10(5) G-CSF-mobilized CD34(+) cells. Hematopoietic differentiation of transplanted progenitors was similar after AMD3100 or G-CSF-mobilization. Thus, AMD3100 mobilized peripheral blood represents a rapidly obtained, highly repopulating source of hematopoietic progenitors for clinical transplantation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-10335872, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-10545519, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-10590044, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-10619866, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-10828007, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-11104786, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-11110686, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-11342460, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-11369624, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-12068293, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-12130497, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-12225788, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-12496427, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-12714578, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-12815382, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-12855591, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-14604975, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-15020611, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-15070669, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-15178579, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-15752146, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-15837815, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-15890685, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-15900288, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-16439684, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-16934081, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-6586833, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-7534140, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-7579367, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-7595706, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-8528100, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-8946831, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9051238, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9108391, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9144235, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9166828, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9193753, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9254660, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9368341, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9389720, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9616148, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9734397, http://linkedlifedata.com/resource/pubmed/commentcorrection/17382247-9933168
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1083-8791
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
398-411
pubmed:dateRevised
2010-12-28
pubmed:meshHeading
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