17345086

Source:http://linkedlifedata.com/resource/pubmed/id/17345086

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006142, umls-concept:C0013203, umls-concept:C0037791, umls-concept:C0038477, umls-concept:C0596577, umls-concept:C0596902, umls-concept:C0683598
pubmed:issue	6
pubmed:dateCreated	2007-9-11
pubmed:abstractText	ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-related protein 1 (MRP1), confer resistance to various anticancer agents. We previously reported that some flavonoids have BCRP-inhibitory activity. Here we show the reversal effects of an extensive panel of flavonoids upon BCRP-, P-gp-, and MRP1-mediated drug resistance.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7806519
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/ABCG2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Hormonal, http://linkedlifedata.com/resource/pubmed/chemical/Flavones, http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids, http://linkedlifedata.com/resource/pubmed/chemical/Multidrug Resistance-Associated..., http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein, http://linkedlifedata.com/resource/pubmed/chemical/Topotecan, http://linkedlifedata.com/resource/pubmed/chemical/acacetin, http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance-associated...
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0344-5704
pubmed:author	pubmed-author:HasegawaHitomiH, pubmed-author:KatayamaKazuhiroK, pubmed-author:MasuyamaKazutoK, pubmed-author:MitsuhashiJunkoJ, pubmed-author:SugimotoYoshikazuY, pubmed-author:YoshiokaShoS
pubmed:issnType	Print
pubmed:volume	60
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	789-97
pubmed:meshHeading	pubmed-meshheading:17345086-ATP-Binding Cassette Transporters, pubmed-meshheading:17345086-Antineoplastic Agents, Hormonal, pubmed-meshheading:17345086-Biological Transport, pubmed-meshheading:17345086-Cell Line, Tumor, pubmed-meshheading:17345086-Cell Proliferation, pubmed-meshheading:17345086-Dose-Response Relationship, Drug, pubmed-meshheading:17345086-Drug Resistance, Neoplasm, pubmed-meshheading:17345086-Drug Screening Assays, Antitumor, pubmed-meshheading:17345086-Flavones, pubmed-meshheading:17345086-Flavonoids, pubmed-meshheading:17345086-Humans, pubmed-meshheading:17345086-Inhibitory Concentration 50, pubmed-meshheading:17345086-K562 Cells, pubmed-meshheading:17345086-Multidrug Resistance-Associated Proteins, pubmed-meshheading:17345086-Neoplasm Proteins, pubmed-meshheading:17345086-P-Glycoprotein, pubmed-meshheading:17345086-Structure-Activity Relationship, pubmed-meshheading:17345086-Topotecan
pubmed:year	2007
pubmed:articleTitle	Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship.
pubmed:affiliation	Department of Chemotherapy, Kyoritsu University of Pharmacy, Tokyo, 105-8512, Japan.
pubmed:publicationType	Journal Article