Source:http://linkedlifedata.com/resource/pubmed/id/17246216
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2010-6-28
|
| pubmed:abstractText |
RpII215(D) (50) (= D50) is a lethal mutation caused by the insertion of a 1.3-kb P element 5' to sequences encoding the largest (215 kilodaltons) subunit of Drosophila RNA polymerase II. In dysgenic males D50 reverted to nonlethality at frequencies ranging from 2.6 to 6.5%. These reversions resulted from loss of P element sequences. Genetic tests of function and restriction enzyme analysis of revertant DNAs revealed that 35% or more of the reversion events were imprecise excisions. Two meiotic mutations that perturb excision repair and postreplication repair (mei-9(a) and mei-41(D5), respectively) had no influence on reversion frequency but may have increased the proportion of imprecise excisions. We suggest that these excisions are by-products of, rather than intermediates in, the transposition process.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-119664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-17248027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-17248751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-17249100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-408811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-4218183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-4625747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-4631264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-6272106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-6320712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17246216-826452
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0016-6731
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
107
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
279-94
|
| pubmed:dateRevised |
2010-9-15
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Frequent Imprecise Excision among Reversions of a P Element-Caused Lethal Mutation in Drosophila.
|
| pubmed:affiliation |
Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
|
| pubmed:publicationType |
Journal Article
|