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rdf:type |
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lifeskim:mentions |
umls-concept:C0005740,
umls-concept:C0025936,
umls-concept:C0026336,
umls-concept:C0026845,
umls-concept:C0034069,
umls-concept:C0178987,
umls-concept:C0205263,
umls-concept:C0458827,
umls-concept:C1441547,
umls-concept:C1511790,
umls-concept:C1523298
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pubmed:dateCreated |
2007-1-25
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pubmed:abstractText |
Epithelial to mesenchymal transition (EMT) in alveolar epithelial cells (AECs) has been widely observed in patients suffering interstitial pulmonary fibrosis. In vitro studies have also demonstrated that AECs could convert into myofibroblasts following exposure to TGF-beta1. In this study, we examined whether EMT occurs in bleomycin (BLM) induced pulmonary fibrosis, and the involvement of bronchial epithelial cells (BECs) in the EMT. Using an alpha-smooth muscle actin-Cre transgenic mouse (alpha-SMA-Cre/R26R) strain, we labelled myofibroblasts in vivo. We also performed a phenotypic analysis of human BEC lines during TGF-beta1 stimulation in vitro.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-10969033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-11020712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-11158319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-11401889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-11549593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-11553712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-11822880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-11923290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-12547711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-14722616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-15269336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-15501477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-15855634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-15946381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-16179636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-16475008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-16618786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-2024710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-3197813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-6333513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-7624356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-78675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-7923625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-9294108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17207287-9916792
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17207287-Actins,
pubmed-meshheading:17207287-Animals,
pubmed-meshheading:17207287-Bleomycin,
pubmed-meshheading:17207287-Cell Differentiation,
pubmed-meshheading:17207287-Cells, Cultured,
pubmed-meshheading:17207287-Disease Models, Animal,
pubmed-meshheading:17207287-Humans,
pubmed-meshheading:17207287-Integrases,
pubmed-meshheading:17207287-Mesoderm,
pubmed-meshheading:17207287-Mice,
pubmed-meshheading:17207287-Mice, Transgenic,
pubmed-meshheading:17207287-Myocytes, Smooth Muscle,
pubmed-meshheading:17207287-Pulmonary Alveoli,
pubmed-meshheading:17207287-Pulmonary Fibrosis,
pubmed-meshheading:17207287-Respiratory Mucosa
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pubmed:year |
2007
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pubmed:articleTitle |
Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse.
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pubmed:affiliation |
Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, 510120, PR China. wuzhuang@126.com <wuzhuang@126.com>
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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