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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-2-6
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pubmed:abstractText |
Inflammation facilitates tumor progression including metastasis. Interleukin-8 (IL-8) is a chemokine that regulates polymorphonuclear neutrophil (PMN) mobilization and activity and we hypothesize that this cytokine influences tumor behavior. We have demonstrated that IL-8 is crucial for PMN-mediated melanoma extravasation under flow conditions. In addition, IL-8 is up-regulated in PMNs upon co-culturing with melanoma cells. Melanoma cells induce IkappaB-alpha degradation in PMNs indicating that NF-kappaB signaling is active in PMNs. Furthermore, the production of IL-8 in PMNs is NF-kappaB dependent. We have further identified that interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) from PMN-melanoma co-cultures synergistically contribute to IkappaB-alpha degradation and IL-8 synthesis in PMNs. Taken together, these findings show that melanoma cells induce PMNs to secrete IL-8 through activation of NF-kappaB and suggest a model in which this interaction promotes a microenvironment that is favorable for metastasis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-10754335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-11242036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-11795669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-12060384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-12108845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-12490959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-12866031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-12960348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-1380488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-14585143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-1497091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-15601752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-1671030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-16912199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-3032419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-7525815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-7552992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-7592998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-7880385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-7922371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-8413215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-8413306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-9024987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17141217-9916078
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-4827
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
313
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
551-9
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:17141217-Cell Communication,
pubmed-meshheading:17141217-Cell Line, Tumor,
pubmed-meshheading:17141217-Cell Movement,
pubmed-meshheading:17141217-Cells, Cultured,
pubmed-meshheading:17141217-Cytokines,
pubmed-meshheading:17141217-Humans,
pubmed-meshheading:17141217-Inflammation,
pubmed-meshheading:17141217-Interleukin-8,
pubmed-meshheading:17141217-Melanoma,
pubmed-meshheading:17141217-NF-kappa B,
pubmed-meshheading:17141217-Neutrophils,
pubmed-meshheading:17141217-Transfection
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pubmed:year |
2007
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pubmed:articleTitle |
Regulation of interleukin-8 expression in melanoma-stimulated neutrophil inflammatory response.
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pubmed:affiliation |
Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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