| pubmed-article:17113202 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17113202 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:17113202 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:17113202 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:17113202 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:17113202 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:17113202 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17113202 | lifeskim:mentions | umls-concept:C2348628 | lld:lifeskim |
| pubmed-article:17113202 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:17113202 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17113202 | pubmed:dateCreated | 2007-1-16 | lld:pubmed |
| pubmed-article:17113202 | pubmed:abstractText | Angiogenesis is a rate-limiting step in the development of tumors. Here, we demonstrate that oral minigene DNA vaccines against murine vascular endothelial growth factor receptor-2 (FLK-1), a self-antigen overexpressed on proliferating endothelial cells in the tumor vasculature, induced protection against tumors of different origin in syngeneic BALB/c mice. This protection is mediated by CD8 T cells, which specifically kill FLK-1(+) endothelial cells, resulting in marked suppression of tumor angiogenesis. More importantly, the minigene vaccine proved to be of similar efficacy as a vaccine encoding the whole FLK-1 gene. These data suggest a FLK-1 minigene vaccine provides a more flexible alternative to the whole gene vaccine and will facilitate their future design and clinical applications in cancer therapy and prevention. | lld:pubmed |
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| pubmed-article:17113202 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17113202 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17113202 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17113202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17113202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17113202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17113202 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17113202 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17113202 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:17113202 | pubmed:author | pubmed-author:ZhouHeH | lld:pubmed |
| pubmed-article:17113202 | pubmed:author | pubmed-author:XiangRongR | lld:pubmed |
| pubmed-article:17113202 | pubmed:author | pubmed-author:ReisfeldRalph... | lld:pubmed |
| pubmed-article:17113202 | pubmed:author | pubmed-author:LuoYunpingY | lld:pubmed |
| pubmed-article:17113202 | pubmed:author | pubmed-author:MarkowitzDoro... | lld:pubmed |
| pubmed-article:17113202 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17113202 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:17113202 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:17113202 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17113202 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17113202 | pubmed:pagination | 1409-15 | lld:pubmed |
| pubmed-article:17113202 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17113202 | pubmed:meshHeading | pubmed-meshheading:17113202... | lld:pubmed |
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| pubmed-article:17113202 | pubmed:meshHeading | pubmed-meshheading:17113202... | lld:pubmed |
| pubmed-article:17113202 | pubmed:meshHeading | pubmed-meshheading:17113202... | lld:pubmed |
| pubmed-article:17113202 | pubmed:meshHeading | pubmed-meshheading:17113202... | lld:pubmed |
| pubmed-article:17113202 | pubmed:meshHeading | pubmed-meshheading:17113202... | lld:pubmed |
| pubmed-article:17113202 | pubmed:meshHeading | pubmed-meshheading:17113202... | lld:pubmed |
| pubmed-article:17113202 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17113202 | pubmed:articleTitle | FLK-1-based minigene vaccines induce T cell-mediated suppression of angiogenesis and tumor protective immunity in syngeneic BALB/c mice. | lld:pubmed |
| pubmed-article:17113202 | pubmed:affiliation | Department of Immunology, The Scripps Research Institute, R218, IMM13, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:17113202 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17113202 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17113202 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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