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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-1-16
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pubmed:abstractText |
Angiogenesis is a rate-limiting step in the development of tumors. Here, we demonstrate that oral minigene DNA vaccines against murine vascular endothelial growth factor receptor-2 (FLK-1), a self-antigen overexpressed on proliferating endothelial cells in the tumor vasculature, induced protection against tumors of different origin in syngeneic BALB/c mice. This protection is mediated by CD8 T cells, which specifically kill FLK-1(+) endothelial cells, resulting in marked suppression of tumor angiogenesis. More importantly, the minigene vaccine proved to be of similar efficacy as a vaccine encoding the whole FLK-1 gene. These data suggest a FLK-1 minigene vaccine provides a more flexible alternative to the whole gene vaccine and will facilitate their future design and clinical applications in cancer therapy and prevention.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-10203751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-10359579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-10779556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-11085538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-11102799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-11282421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-11429607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-11710736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-12415261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-12488431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-12857959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-15199414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-15578105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-15920006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-1656371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-1717995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-2469442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-8574960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-8758924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-9002217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-9008168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-9181567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-9557871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113202-9666712
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1409-15
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17113202-Administration, Oral,
pubmed-meshheading:17113202-Animals,
pubmed-meshheading:17113202-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17113202-Cancer Vaccines,
pubmed-meshheading:17113202-Cell Line, Tumor,
pubmed-meshheading:17113202-Colonic Neoplasms,
pubmed-meshheading:17113202-Endothelial Cells,
pubmed-meshheading:17113202-Female,
pubmed-meshheading:17113202-Mammary Neoplasms, Experimental,
pubmed-meshheading:17113202-Mice,
pubmed-meshheading:17113202-Mice, Inbred BALB C,
pubmed-meshheading:17113202-Neoplasms, Experimental,
pubmed-meshheading:17113202-Neovascularization, Pathologic,
pubmed-meshheading:17113202-Vaccines, DNA,
pubmed-meshheading:17113202-Vascular Endothelial Growth Factor Receptor-2
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pubmed:year |
2007
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pubmed:articleTitle |
FLK-1-based minigene vaccines induce T cell-mediated suppression of angiogenesis and tumor protective immunity in syngeneic BALB/c mice.
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pubmed:affiliation |
Department of Immunology, The Scripps Research Institute, R218, IMM13, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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