Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-7-19
|
| pubmed:abstractText |
Single-channel recordings were made using cell-free membrane patches (outside-out configuration) isolated from pheochromocytoma PC12 cells. ATP (50 microM) activated single channel currents in the isolated patches and the currents inactivated with a half-decay time of about 5s. The single channel conductance was about 13 pS in external solution with 140 mM Na. The amplitudes of the single-channel currents were decreased when external Ca was increased from 1.8 to 16.2 mM, suggesting that Ca blocks ion permeation through the channel. These properties of single-channel currents may underlie those of the macroscopic current.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
119
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5-8
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:1711181-Adenosine Triphosphate,
pubmed-meshheading:1711181-Adrenal Gland Neoplasms,
pubmed-meshheading:1711181-Calcium,
pubmed-meshheading:1711181-Cell-Free System,
pubmed-meshheading:1711181-Electric Conductivity,
pubmed-meshheading:1711181-Electrophysiology,
pubmed-meshheading:1711181-Extracellular Space,
pubmed-meshheading:1711181-Ion Channels,
pubmed-meshheading:1711181-Osmolar Concentration,
pubmed-meshheading:1711181-Pheochromocytoma,
pubmed-meshheading:1711181-Tumor Cells, Cultured
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
ATP-activated single-channel currents recorded from cell-free patches of pheochromocytoma PC12 cells.
|
| pubmed:affiliation |
Division of Pharmacology, National Institute of Hygienic Sciences, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|