|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0009325,
umls-concept:C0016030,
umls-concept:C0017262,
umls-concept:C0030705,
umls-concept:C0036421,
umls-concept:C0110610,
umls-concept:C0185117,
umls-concept:C0332307,
umls-concept:C1099354,
umls-concept:C1123023,
umls-concept:C1280500,
umls-concept:C2911684
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2006-11-19
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|
pubmed:abstractText |
Systemic sclerosis (SSc) is characterized by an excessive production of extracellular matrix. It is widely accepted that fibrosis is induced by transforming growth factor (TGF)-beta in the early stage and is subsequently maintained by connective tissue growth factor (CTGF). CTGF is a cysteine-rich mitogenic peptide that has been involved in various fibrotic disorders and can be induced in fibroblasts by activation with TGF-beta.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
|
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pubmed:month |
Dec
|
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pubmed:issn |
0007-0963
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1145-53
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17107381-Blotting, Western,
pubmed-meshheading:17107381-Collagen Type I,
pubmed-meshheading:17107381-Collagen Type III,
pubmed-meshheading:17107381-Connective Tissue Growth Factor,
pubmed-meshheading:17107381-Fibroblasts,
pubmed-meshheading:17107381-Humans,
pubmed-meshheading:17107381-Immediate-Early Proteins,
pubmed-meshheading:17107381-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:17107381-RNA, Small Interfering,
pubmed-meshheading:17107381-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17107381-Scleroderma, Systemic,
pubmed-meshheading:17107381-Transfection,
pubmed-meshheading:17107381-Transforming Growth Factor beta
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|
pubmed:year |
2006
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|
pubmed:articleTitle |
Effect of small interfering RNA on the expression of connective tissue growth factor and type I and III collagen in skin fibroblasts of patients with systemic sclerosis.
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pubmed:affiliation |
Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. xiaorong@medmail.com.cn
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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