|
pubmed:abstractText |
L-homocysteine and/or L-homocystine interact in vivo with albumin and other extracellular proteins by forming mixed-disulfide conjugates. Because of its extremely rich cysteine content, we hypothesized that metallothionein, a ubiquitous intracellular zinc-chaperone and superoxide anion radical scavenger, reacts with L-homocysteine and that homocysteinylated-metallothionein suffers loss of function.
|
|
pubmed:affiliation |
Department Cell Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195, USA.
|
