Linked Life Data

16955970

Source:http://linkedlifedata.com/resource/pubmed/id/16955970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2006-9-7
pubmed:abstractText
Improvements in preparations of tissue activator and plasminogen and termination of activation by epsilon aminocaproic acid have permitted the use of a quantitative caseinolytic assay for the measurement of the plasmin formed. The following data indicate that the activation of plasminogen by tissue activator is catalytic: a) Biphasic curve obtained when velocity was plotted against plasminogen concentration. b) First order kinetics. c) Dependence of the turnover number on tissue activator concentration. The temperature and pH stability of tissue activator were similar to those reported for urokinase. Since both of these enzymes have now been shown to activate plasminogen by a catalytic mechanism, these data support the suggestion that urokinase may be an excretory form of tissue activator which has been released into the circulation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0340-5338
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
116-26
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1965
pubmed:articleTitle
Mechanism of action and some properties of a tissue activator of plasminogen.
pubmed:affiliation
Department of Physiology, Yale University School of Medicine, New Haven, Connecticut, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural