rdf:type |
|
lifeskim:mentions |
umls-concept:C0005527,
umls-concept:C0006142,
umls-concept:C0069515,
umls-concept:C0205179,
umls-concept:C0205195,
umls-concept:C0242957,
umls-concept:C0246421,
umls-concept:C0728747,
umls-concept:C0871261,
umls-concept:C1446409,
umls-concept:C1515021,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
pubmed:issue |
1
|
pubmed:dateCreated |
2007-7-4
|
pubmed:abstractText |
Estrogen receptor (ER) and/or progesterone receptor expression occurs in approximately 50% HER2 positive (HER2+) breast cancers and cross-talk between the estrogen and HER2 pathways promotes endocrine therapy resistance. The efficacy of the aromatase inhibitor letrozole in combination with trastuzumab was therefore tested in a Phase 2 study.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/letrozole,
http://linkedlifedata.com/resource/pubmed/chemical/trastuzumab
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0167-6806
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
102
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
43-9
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:16897431-Adult,
pubmed-meshheading:16897431-Aged,
pubmed-meshheading:16897431-Antibodies, Monoclonal,
pubmed-meshheading:16897431-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:16897431-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16897431-Breast Neoplasms,
pubmed-meshheading:16897431-Female,
pubmed-meshheading:16897431-Humans,
pubmed-meshheading:16897431-Immunohistochemistry,
pubmed-meshheading:16897431-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16897431-Middle Aged,
pubmed-meshheading:16897431-Nitriles,
pubmed-meshheading:16897431-Receptor, erbB-2,
pubmed-meshheading:16897431-Receptors, Estrogen,
pubmed-meshheading:16897431-Triazoles
|
pubmed:year |
2007
|
pubmed:articleTitle |
The combination of letrozole and trastuzumab as first or second-line biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers.
|
pubmed:affiliation |
Siteman Comprehensive Cancer Center, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8056, St Louis, MO, USA
|
pubmed:publicationType |
Journal Article,
Clinical Trial, Phase II
|