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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-3-7
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pubmed:abstractText |
A synthetic peptide (CKS-17) homologous to a highly conserved region of the retroviral transmembrane protein p15E was tested for its effect on receptor expression on monocytes. The CKS-17 amino acid sequence is present in several retroviruses including human T-cell lymphotropic virus types I and II and human immunodeficiency virus. The CKS-17 peptide has been previously shown to inhibit monocyte superoxide production, natural killer cell activity, polyclonal B-cell activation, and monocyte-mediated killing by inactivation of interleukin-1. In this study, we demonstrated that the anti-CD4 monoclonal antibody OKT4 binds strongly in vitro to CKS-17-treated human blood monocytes, whereas other antibodies tested were not reactive. This observed binding was the result of direct interaction of OKT4 antibody with the CKS-17 peptide. Moreover, a partial homology was found in amino acid sequence analysis of the CD4 epitope and the CKS-17 peptide.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-2433333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-2821111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-2968406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-2990730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-2996136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-3025858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-3027178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-3127528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-3701057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-4974753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-6504158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1688871-7299347
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1688871-Amino Acid Sequence,
pubmed-meshheading:1688871-Antibodies, Monoclonal,
pubmed-meshheading:1688871-Antigens, CD4,
pubmed-meshheading:1688871-Antigens, Viral,
pubmed-meshheading:1688871-Cell Line, Transformed,
pubmed-meshheading:1688871-Cross Reactions,
pubmed-meshheading:1688871-Epitopes,
pubmed-meshheading:1688871-Humans,
pubmed-meshheading:1688871-Molecular Sequence Data,
pubmed-meshheading:1688871-Monocytes,
pubmed-meshheading:1688871-Peptides,
pubmed-meshheading:1688871-Retroviridae Proteins,
pubmed-meshheading:1688871-Viral Envelope Proteins
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pubmed:year |
1990
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pubmed:articleTitle |
Synthetic peptide homologous to the envelope proteins of retroviruses shares a cross-reacting epitope with the CD4 receptor.
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pubmed:affiliation |
Division of Allergy-Immunology-Bone Marrow Transplantation, Children's Hospital of Philadelphia, Pennsylvania.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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