Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-10-9
pubmed:abstractText
Renal volume regulation is modulated by the action of cyclooxygenases (COX) and the resulting generation of prostanoids. Epithelial expression of COX isoforms in the cortex directs COX-1 to the distal convolutions and cortical collecting duct, and COX-2 to the thick ascending limb. Partly colocalized are prostaglandin E synthase (PGES), the downstream enzyme for renal prostaglandin E(2) (PGE(2)) generation, and the EP receptors type 1 and 3. COX-1 and related components were studied in two kidney-one clip (2K1C) Goldblatt hypertensive rats with combined chronic ANG II or bradykinin B(2) receptor blockade using candesartan (cand) or the B(2) antagonist Hoechst 140 (Hoe). Rats (untreated sham, 2K1C, sham + cand, 2K1C + cand, sham + Hoe, 2K1C + Hoe) were treated to map expression of parameters controlling PGE(2) synthesis. In 2K1C, cortical COX isoforms did not change uniformly. COX-2 changed in parallel with NO synthase 1 (NOS1) expression with a raise in the clipped, but a decrease in the nonclipped side. By contrast, COX-1 and PGES were uniformly downregulated in both kidneys, along with reduced urinary PGE(2) levels, and showed no clear relations with the NO status. ANG II receptor blockade confirmed negative regulation of COX-2 by ANG II but blunted the decrease in COX-1 selectively in nonclipped kidneys. B(2) receptor blockade reduced COX-2 induction in 2K1C but had no clear effect on COX-1. We suggest that in 2K1C, COX-1 and PGES expression may fail to oppose the effects of renovascular hypertension through reduced prostaglandin signaling in late distal tubule and cortical collecting duct.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor..., http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase, http://linkedlifedata.com/resource/pubmed/chemical/Nos1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Ptger1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Ptger3 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Ptgs1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Ptgs2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP1..., http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP3..., http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles, http://linkedlifedata.com/resource/pubmed/chemical/candesartan, http://linkedlifedata.com/resource/pubmed/chemical/icatibant
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1931-857X
pubmed:author
pubmed:issnType
Print
pubmed:volume
291
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
F987-94
pubmed:dateRevised
2011-4-28
pubmed:meshHeading
pubmed-meshheading:16788145-Adrenergic beta-Antagonists, pubmed-meshheading:16788145-Angiotensin II Type 1 Receptor Blockers, pubmed-meshheading:16788145-Animals, pubmed-meshheading:16788145-Benzimidazoles, pubmed-meshheading:16788145-Blood Pressure, pubmed-meshheading:16788145-Bradykinin, pubmed-meshheading:16788145-Cyclic GMP, pubmed-meshheading:16788145-Cyclooxygenase 1, pubmed-meshheading:16788145-Cyclooxygenase 2, pubmed-meshheading:16788145-Dinoprostone, pubmed-meshheading:16788145-Disease Models, Animal, pubmed-meshheading:16788145-Hypertension, Renovascular, pubmed-meshheading:16788145-Kidney Cortex, pubmed-meshheading:16788145-Kidney Tubules, Collecting, pubmed-meshheading:16788145-Kidney Tubules, Distal, pubmed-meshheading:16788145-Loop of Henle, pubmed-meshheading:16788145-Male, pubmed-meshheading:16788145-Membrane Proteins, pubmed-meshheading:16788145-Nitric Oxide, pubmed-meshheading:16788145-Nitric Oxide Synthase, pubmed-meshheading:16788145-Rats, pubmed-meshheading:16788145-Rats, Sprague-Dawley, pubmed-meshheading:16788145-Receptors, Prostaglandin E, pubmed-meshheading:16788145-Receptors, Prostaglandin E, EP1 Subtype, pubmed-meshheading:16788145-Receptors, Prostaglandin E, EP3 Subtype, pubmed-meshheading:16788145-Surgical Instruments, pubmed-meshheading:16788145-Tetrazoles
pubmed:year
2006
pubmed:articleTitle
Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat).
pubmed:affiliation
Charité Universitätsmedizin Berlin, Institut für Vegetative Anatomie, Philippstr. 12, 10115 Berlin, Germany.
pubmed:publicationType
Journal Article