| pubmed-article:1675512 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1675512 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:1675512 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:1675512 | lifeskim:mentions | umls-concept:C0225360 | lld:lifeskim |
| pubmed-article:1675512 | lifeskim:mentions | umls-concept:C0001271 | lld:lifeskim |
| pubmed-article:1675512 | lifeskim:mentions | umls-concept:C1517927 | lld:lifeskim |
| pubmed-article:1675512 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:1675512 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:1675512 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1675512 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1675512 | pubmed:dateCreated | 1991-7-18 | lld:pubmed |
| pubmed-article:1675512 | pubmed:abstractText | We have examined the histological and cytoskeletal changes in rat connective tissues induced by subcutaneous perfusion with cytokines. Granulocyte macrophage-colony stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha), interleukin-1-alpha (IL-1-alpha), transforming growth factor-beta (TGF-beta) and platelet-derived growth factor (PDGF) produced a significant fibroblast accumulation, neovascular development and a weak to moderate leukocyte infiltration, while interleukin-2 (IL-2) and gamma-interferon (gamma-IFN) induced intense mononucleated leukocyte infiltration. Immunofluorescence staining showed that accumulated fibroblastic cells were positive for alpha-smooth muscle (SM) actin (but negative for the desmin and muscle myosin) only in GM-CSF-treated tissues. Electron microscopic examination established that a significant proportion of fibroblastic cell in GM-CSF-, IL-1-alpha- or TGF-beta-treated animals were typical myofibroblasts. Only in GM-CSF-treated animals did microfilament bundles of myofibroblasts contain alpha-SM actin, when examined by immuno electron microscopy. Our results suggest that locally applied cytokines induce the formation of distinct granulation tissues. In particular, GM-CSF stimulates alpha-SM actin synthesis in myofibroblasts, illustrating an unexpected extra-hematopoietic in vivo effect of this factor. | lld:pubmed |
| pubmed-article:1675512 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1675512 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1675512 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1675512 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1675512 | pubmed:issn | 0340-6075 | lld:pubmed |
| pubmed-article:1675512 | pubmed:author | pubmed-author:GabbianiGG | lld:pubmed |
| pubmed-article:1675512 | pubmed:author | pubmed-author:SappinoA PAP | lld:pubmed |
| pubmed-article:1675512 | pubmed:author | pubmed-author:Rubbia-Brandt... | lld:pubmed |
| pubmed-article:1675512 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1675512 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:1675512 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1675512 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1675512 | pubmed:pagination | 73-82 | lld:pubmed |
| pubmed-article:1675512 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1675512 | pubmed:meshHeading | pubmed-meshheading:1675512-... | lld:pubmed |
| pubmed-article:1675512 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1675512 | pubmed:articleTitle | Locally applied GM-CSF induces the accumulation of alpha-smooth muscle actin containing myofibroblasts. | lld:pubmed |
| pubmed-article:1675512 | pubmed:affiliation | Department of Pathology, University of Geneva, Switzerland. | lld:pubmed |
| pubmed-article:1675512 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1675512 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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