16714073

pubmed:Citation

25

We studied the association between class II human leukocyte antigen (HLA)-DRB1*0301 presented measles virus (MV) peptide-specific cytokine responses and DQB1 and DPB1 alleles among 313 individuals who received two doses of measles-mumps-rubella-II vaccine. The overall median IFN-gamma secretion levels (first and third quartiles) for the 19-amino acid MV phosphoprotein (MV-P)- and 14-amino acid MV nucleoprotein (MV-N)-derived peptides were 27.7 pg/ml (1.8, 109.4) and 1.9 pg/ml (-6.2, 13.0), respectively; median IL-4 secretion levels were -0.6 pg/ml (-7.1, 6.2) and 2.4 pg/ml (-3.2, 9.3), respectively. Primary statistical analyses were adjusted for previously identified DRB1 associations. A marginally significant increase in the frequency of the DQB1*0604 (p=0.02) allele was found among subjects who demonstrated detectable IL-4 levels to the MV-P peptide. Further, DPB1*0201 (p=0.02) and DPB1*1301 (p=0.09) alleles provided suggestive evidence of an association with MV-P-induced IL-4 secretion. Examination of IFN-gamma responses to MV-P and MV-N indicated that none of the individual alleles of the DQB1 and DPB1 loci were associated with peptide-induced T cell response. An increase in the frequency of DPB1*0501 (p=0.01) was found among subjects who failed to produce MV-N peptide-specific IL-4 responses. These data further confirm that HLA-DRB1 alleles are the major restriction molecules for MV-P and MV-N measles virus antigen presentation to T cells. We speculate that MV-P and MV-N peptides derived from DRB1*0301 could potentially be recognized in association with different HLA molecules, including DQB1 and DPB1; however, statistical adjustments for the effect of HLA-DR locus could potentially alter these genetic relationships. This concept provides important information supporting the use of promiscuous peptides in a peptide-based vaccine approach.

http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-12919753, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-14221879, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-14671086, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-15099769, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-15603879, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-1658152, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-1718405, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-2212993, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-2419286, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-2481588, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-3032874, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-3140715, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-6182089, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-6186920, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-7625645, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-8101549, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-8157465, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-8519092, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-9281519, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-9486959, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-9497784, http://linkedlifedata.com/resource/pubmed/commentcorrection/16714073-9822281

http://linkedlifedata.com/resource/pubmed/journal/8406899

http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DP Antigens, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ beta-Chains, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQB1 antigen, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1*03:01 antigen, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4, http://linkedlifedata.com/resource/pubmed/chemical/Measles-Mumps-Rubella Vaccine, http://linkedlifedata.com/resource/pubmed/chemical/Peptides

Jun

pubmed-author:OvsyannikovaInna GIG, pubmed-author:PolandGregory AGA, pubmed-author:VierkantRobert ARA

19

NLM

5381-9

pubmed-meshheading:16714073-Adolescent, pubmed-meshheading:16714073-Alleles, pubmed-meshheading:16714073-Amino Acid Sequence, pubmed-meshheading:16714073-Child, pubmed-meshheading:16714073-Cytokines, pubmed-meshheading:16714073-Female, pubmed-meshheading:16714073-HLA-DP Antigens, pubmed-meshheading:16714073-HLA-DQ Antigens, pubmed-meshheading:16714073-HLA-DQ beta-Chains, pubmed-meshheading:16714073-HLA-DR Antigens, pubmed-meshheading:16714073-HLA-DRB1 Chains, pubmed-meshheading:16714073-Humans, pubmed-meshheading:16714073-Interferon-gamma, pubmed-meshheading:16714073-Interleukin-4, pubmed-meshheading:16714073-Male, pubmed-meshheading:16714073-Measles virus, pubmed-meshheading:16714073-Measles-Mumps-Rubella Vaccine, pubmed-meshheading:16714073-Molecular Sequence Data, pubmed-meshheading:16714073-Peptides, pubmed-meshheading:16714073-Polymorphism, Genetic

Importance of HLA-DQ and HLA-DP polymorphisms in cytokine responses to naturally processed HLA-DR-derived measles virus peptides.

Journal Article, Research Support, N.I.H., Extramural