rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-5-2
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pubmed:abstractText |
Our previous study suggested that suppression by cepharanthin of tumor necrosis factor-a (TNF-a)-induced matrix metalloproteinase-9 (MMP-9) could prevent destruction of the acinar structure in the salivary glands of patients with Sjögren's syndrome (SS). In this study, we observed that in vivo administration of cepharanthin prevented severe damage to acinar tissues in the murine model of human SS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Benzylisoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type IV,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rela protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/cepharanthine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
912-20
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16652422-Alkaloids,
pubmed-meshheading:16652422-Animals,
pubmed-meshheading:16652422-Apoptosis,
pubmed-meshheading:16652422-Benzylisoquinolines,
pubmed-meshheading:16652422-Carrier Proteins,
pubmed-meshheading:16652422-Collagen Type IV,
pubmed-meshheading:16652422-Female,
pubmed-meshheading:16652422-I-kappa B Proteins,
pubmed-meshheading:16652422-Immunohistochemistry,
pubmed-meshheading:16652422-Lacrimal Apparatus,
pubmed-meshheading:16652422-Matrix Metalloproteinase 9,
pubmed-meshheading:16652422-Mice,
pubmed-meshheading:16652422-Mice, Mutant Strains,
pubmed-meshheading:16652422-Neoplasm Proteins,
pubmed-meshheading:16652422-Salivary Glands,
pubmed-meshheading:16652422-Sjogren's Syndrome,
pubmed-meshheading:16652422-Transcription Factor RelA
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pubmed:year |
2006
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pubmed:articleTitle |
Cepharanthin, a biscoclaurine alkaloid, prevents destruction of acinar tissues in murine Sjögren's syndrome.
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pubmed:affiliation |
Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Tokushima, Japan. azumasa@dent.tokushima-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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