Linked Life Data

16650849

Source:http://linkedlifedata.com/resource/pubmed/id/16650849

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-7-3
pubmed:abstractText
The enantiomeric separation of cetirizine and oxfendazole on a Chiralpak AD column using subcritical fluid chromatography has been studied in this work. The enantioseparation of cetirizine was only possible when 2-propanol was used as a modifier, obtaining better results in presence of the additives triethylamine (TEA) and trifluoroacetic acid (TFAA). On the contrary, 2-propanol provided the lowest enantioresolutions for oxfendazole, in this case the best results in terms of high resolution and short analysis time were obtained with ethanol. The study of the temperature effect revealed that in the case of cetirizine using 2-propanol, and oxfendazole using methanol, the separation was enthalpy-driven and the isoelution temperature was above the working range. Using ethanol or 2-propanol, the results showed that the oxfendazole enantioseparation was entropically driven and the isoelution temperatures were below the range studied.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9673
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
1121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
268-73
pubmed:dateRevised
2009-1-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Study of the enantiomeric separation of oxfendazole and cetirizine using subcritical fluid chromatography on an amylose-based column.
pubmed:affiliation
Department of Analytical Chemistry, Faculty of Science, University of Valladolid, Prado de la Magdalena s/n, 47005 Valladolid, Spain. ltoribio@qa.uva.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't