Source:http://linkedlifedata.com/resource/pubmed/id/16618193
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2006-4-18
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pubmed:abstractText |
Ultrasonic imaging is a widely available, noninvasive, and cost-effective diagnostic modality, but vessels smaller than 200 mum in diameter are impossible to visualize. Commercial ultrasound contrast agents (UCAs), consisting of encapsulated gas microbubbles injected intravenously, enable only a qualitative visualization of the microvascularization for a short period of time since they are rather unstable. In a strategy to develop more stable UCAs, we designed a process to obtain nano/microcapsules with a single core of liquid perfluorocarbons within a biodegradable polymeric shell of homogeneous thickness. The polymer shell should improve the stability of the capsules as compared to UCAs stabilized by a monomolecular layer, while the acoustic impedance of the perfluorocarbons should ensure their echogenicity. These capsules have been optimized to encapsulate several liquid perfluorocarbons: perfluorohexane, perfluorodecalin, and perfluorooctyl bromide. The system is rather versatile: the mean size of the capsules can be adjusted between 70 nm and 25 microm and the thickness-to-radius ratio (T/R) can be easily modulated by simply modifying the polymer-to-perfluorocarbon ratio. T/R does not depend on the size of the capsules and is between 0.2 and 0.6. The dependence of the echogenic properties of the capsules with their size and their T/R has yet to be studied experimentally before this system can be evaluated in vivo.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0743-7463
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4397-402
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pubmed:meshHeading |
pubmed-meshheading:16618193-Contrast Media,
pubmed-meshheading:16618193-Fluorocarbons,
pubmed-meshheading:16618193-Freeze Fracturing,
pubmed-meshheading:16618193-Humans,
pubmed-meshheading:16618193-Microbubbles,
pubmed-meshheading:16618193-Microcirculation,
pubmed-meshheading:16618193-Microscopy, Confocal,
pubmed-meshheading:16618193-Microscopy, Electron, Scanning,
pubmed-meshheading:16618193-Nanocapsules,
pubmed-meshheading:16618193-Particle Size,
pubmed-meshheading:16618193-Polymers,
pubmed-meshheading:16618193-Ultrasonography
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pubmed:year |
2006
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pubmed:articleTitle |
Polymeric nano/microcapsules of liquid perfluorocarbons for ultrasonic imaging: physical characterization.
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pubmed:affiliation |
UMR CNRS 8612, School of Pharmacy, Univ. Paris Sud, France, Facoltà di Farmacia, Università degli Studi di Torino, Torino, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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