Linked Life Data

16525044

Source:http://linkedlifedata.com/resource/pubmed/id/16525044

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2006-3-9
pubmed:abstractText
Determining the contribution of a single type of ion channel to information processing within a neuron requires not only knowledge of the properties of the channel but also understanding of its function within a complex system. We studied the contribution of slow delayed rectifier K+ channels to neural coding in Drosophila photoreceptors by combining genetic and electrophysiological approaches with biophysical modeling. We show that the Shab gene encodes the slow delayed rectifier K+ channel and identify a novel voltage-gated K+ conductance. Analysis of the in vivo recorded voltage responses together with their computer-simulated counterparts demonstrates that Shab channels in Drosophila photoreceptors attenuate the light-induced depolarization and prevent response saturation in bright light. We also show that reduction of the Shab conductance in mutant photoreceptors is accompanied by a proportional drop in their input resistance. This reduction in input resistance partially restores the signaling range, sensitivity, and dynamic coding of light intensities of Shab photoreceptors to those of the wild-type counterparts. However, loss of the Shab channels may affect both the energy efficiency of coding and the processing of natural stimuli. Our results highlight the role of different types of voltage-gated K+ channels in the performance of the photoreceptors and provide insight into functional robustness against the perturbation of specific ion channel composition.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
8
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2652-60
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16525044-Action Potentials, pubmed-meshheading:16525044-Analysis of Variance, pubmed-meshheading:16525044-Animals, pubmed-meshheading:16525044-Animals, Genetically Modified, pubmed-meshheading:16525044-Dose-Response Relationship, Radiation, pubmed-meshheading:16525044-Drosophila, pubmed-meshheading:16525044-Drosophila Proteins, pubmed-meshheading:16525044-Electric Stimulation, pubmed-meshheading:16525044-Light, pubmed-meshheading:16525044-Membrane Potentials, pubmed-meshheading:16525044-Models, Biological, pubmed-meshheading:16525044-Neural Conduction, pubmed-meshheading:16525044-Neurons, pubmed-meshheading:16525044-Patch-Clamp Techniques, pubmed-meshheading:16525044-Photoreceptor Cells, Invertebrate, pubmed-meshheading:16525044-Shab Potassium Channels, pubmed-meshheading:16525044-Shaker Superfamily of Potassium Channels
pubmed:year
2006
pubmed:articleTitle
Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels.
pubmed:affiliation
Division of Biophysics and Biocenter Oulu, Department of Physical Sciences, University of Oulu, 90014 Oulun Yliopisto, Finland.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't