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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-3
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pubmed:abstractText |
Some authors have suggested that chronic octreotide use enhances the efficiency of radiolabeled somatostatin receptor (sst) imaging. Conversely, desensitization of sst on tumor tissue (tachyphylaxis) may occur occasionally in patients on chronic octreotide therapy. Assuming that chronic exposure to octreotide induces tachyphylaxis, we hypothesized that chronic exposure of sst subtype 2 (sst2)-expressing cells to octreotide would downregulate binding of 111In-pentetreotide to sst and that this downregulation would be due to a reduction in the gene copy number for sst2.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
354-9
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16455643-Cell Line, Tumor,
pubmed-meshheading:16455643-Down-Regulation,
pubmed-meshheading:16455643-Drug Interactions,
pubmed-meshheading:16455643-Humans,
pubmed-meshheading:16455643-Neuroblastoma,
pubmed-meshheading:16455643-Octreotide,
pubmed-meshheading:16455643-Pancreatic Neoplasms,
pubmed-meshheading:16455643-Radiopharmaceuticals,
pubmed-meshheading:16455643-Receptors, Somatostatin,
pubmed-meshheading:16455643-Somatostatin
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pubmed:year |
2006
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pubmed:articleTitle |
In vitro modeling of the clinical interactions between octreotide and 111In-pentetreotide: is there evidence of somatostatin receptor downregulation?
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pubmed:affiliation |
Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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