Source:http://linkedlifedata.com/resource/umls/id/C0949469
NCI: A multicellular process that regulates the number of transmembrane receptors, by means of increased internalization or decreased expression of the transmembrane receptor. This process is involved in dampening the response to extracellular signals.,MSH: A negative regulatory process that decreases ligand-receptor interactions. Reduction in receptor binding after ligand exposure can result from the internalization of ligand-receptor complex, an increase in receptor degradation, and/or a decrease in gene expression resulting in a decrease in receptor biosynthesis.