| pubmed-article:16424009 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C1706515 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0540511 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0025543 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0059239 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C1565434 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C1704640 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0299136 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16424009 | lifeskim:mentions | umls-concept:C0331858 | lld:lifeskim |
| pubmed-article:16424009 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16424009 | pubmed:dateCreated | 2006-1-20 | lld:pubmed |
| pubmed-article:16424009 | pubmed:abstractText | Accumulating evidence reveals a significant correlation between angiopoietin 2 (Ang2) expression and tumor invasion and metastasis in various human cancers, but the major focus of recent studies has been on the angiogenic effects of Ang2. We recently reported that Ang2-stimulated glioma cell invasion results from the up-regulation and activation of matrix metalloprotease 2 (MMP-2) in tumor cells. In this study, we identify a novel mechanism by which Ang2 stimulates MMP-2 expression leading to glioma cell invasion. We show that Ang2 interacts with alpha(v)beta(1) integrin in Tie2-deficient human glioma cells, activating focal adhesion kinase (FAK), p130(Cas), extracellular signal-regulated protein kinase (ERK) 1/2, and c-jun NH(2)-terminal kinase (JNK) and substantially enhancing MMP-2 expression and secretion. The Ang2/alpha(v)beta(1) integrin signaling pathway was attenuated by functional inhibition of beta(1) and alpha(v) integrins, FAK, p130(Cas), ERK1/2, and JNK. Furthermore, expression of a negative regulator of FAK, FAK-related nonkinase, by U87MG/Ang2-expressing glioma xenografts suppressed Ang2-induced MMP-2 expression and glioma cell infiltration in the murine brain. These data establish a functional link between Ang2 interaction with alpha(v)beta(1) integrin and glioma cell invasion through the FAK/p130(Cas)/ERK1/2 and JNK-mediated signaling pathway. | lld:pubmed |
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| pubmed-article:16424009 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16424009 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16424009 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16424009 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16424009 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16424009 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:16424009 | pubmed:author | pubmed-author:GuoPingP | lld:pubmed |
| pubmed-article:16424009 | pubmed:author | pubmed-author:ChengShi-Yuan... | lld:pubmed |
| pubmed-article:16424009 | pubmed:author | pubmed-author:HuBoB | lld:pubmed |
| pubmed-article:16424009 | pubmed:author | pubmed-author:SchlaepferDav... | lld:pubmed |
| pubmed-article:16424009 | pubmed:author | pubmed-author:JarzynkaMicha... | lld:pubmed |
| pubmed-article:16424009 | pubmed:author | pubmed-author:ImanishiYorih... | lld:pubmed |
| pubmed-article:16424009 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16424009 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16424009 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:16424009 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16424009 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16424009 | pubmed:pagination | 775-83 | lld:pubmed |
| pubmed-article:16424009 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:16424009 | pubmed:meshHeading | pubmed-meshheading:16424009... | lld:pubmed |
| pubmed-article:16424009 | pubmed:meshHeading | pubmed-meshheading:16424009... | lld:pubmed |
| pubmed-article:16424009 | pubmed:meshHeading | pubmed-meshheading:16424009... | lld:pubmed |
