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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-4
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pubmed:abstractText |
Serotonin (5-hydroxytryptamine; 5-HT) overproduction is responsible for cardiac valvular disease in patients with carcinoid tumors. Reduced 5-HT inactivation is one proposed mechanism of the valvulopathy observed in individuals treated with the appetite suppressants fenfluramine and phentermine. One key protein limiting systemic availability of 5-HT is the 5-HT transporter (5-HTT) expressed by platelets and pulmonary vascular cells; 5-HTT is responsible for 5-HT uptake and subsequent inactivation of the amine passing through the lung. Here we investigated whether 5-HTT-deficient (5-HTT-KO) mice developed structural and/or functional cardiac abnormalities and valvulopathy.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:AdnotSS,
pubmed-author:Benhaiem-SigauxNN,
pubmed-author:BrouriFF,
pubmed-author:EddahibiSS,
pubmed-author:HamonMM,
pubmed-author:HanounNN,
pubmed-author:KirschMM,
pubmed-author:LanfumeyLL,
pubmed-author:LechatPP,
pubmed-author:Mekontso-DessapAA,
pubmed-author:PascalOO,
pubmed-author:SeifII
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16380550-Animals,
pubmed-meshheading:16380550-Fibroblasts,
pubmed-meshheading:16380550-Fibrosis,
pubmed-meshheading:16380550-Heart Valve Diseases,
pubmed-meshheading:16380550-Humans,
pubmed-meshheading:16380550-Hydroxyindoleacetic Acid,
pubmed-meshheading:16380550-Male,
pubmed-meshheading:16380550-Mice,
pubmed-meshheading:16380550-Mice, Knockout,
pubmed-meshheading:16380550-Myocardium,
pubmed-meshheading:16380550-RNA, Messenger,
pubmed-meshheading:16380550-Receptor, Serotonin, 5-HT1B,
pubmed-meshheading:16380550-Serotonin,
pubmed-meshheading:16380550-Serotonin Plasma Membrane Transport Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 651, Département de Physiologie, Université Paris XII, CHU Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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