rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-11-3
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pubmed:abstractText |
INI1/hSNF5/BAF47 is a core component of the hSWI/ SNF ATP-dependent chromatin remodeling complex, and it has been implicated in regulating gene expression, cell division and tumorigenesis. We investigated whether INI1/hSNF5/BAF47 functions in activation of the colony stimulating factor 1 (CSF1) promoter in HeLa cells. Overexpression of INI1/hSNF5/BAF47 promoted CSF1 transcription, and siRNA targeting INI1/hSNF5/ BAF47 (siINI1) strongly inhibited the activity of the CSF1 promoter. We demonstrated that all conserved domains of INI1/hSNF5/BAF47 are needed for CSF1 transcription. ChIP experiment showed that INI1/ hSNF5/BAF47 is recruited to the region of the CSF1 promoter. Taken together, these results indicate that INI1/hSNF5/BAF47 is involved in activation of the CSF1 promoter.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Colony-Stimulating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1016-8478
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16267391-Cell Culture Techniques,
pubmed-meshheading:16267391-Chromatin Assembly and Disassembly,
pubmed-meshheading:16267391-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:16267391-DNA-Binding Proteins,
pubmed-meshheading:16267391-Gene Expression Regulation,
pubmed-meshheading:16267391-HeLa Cells,
pubmed-meshheading:16267391-Humans,
pubmed-meshheading:16267391-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:16267391-Plasmids,
pubmed-meshheading:16267391-Promoter Regions, Genetic,
pubmed-meshheading:16267391-RNA, Messenger,
pubmed-meshheading:16267391-RNA, Small Interfering,
pubmed-meshheading:16267391-Repressor Proteins,
pubmed-meshheading:16267391-Transcription, Genetic,
pubmed-meshheading:16267391-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Chromatin-remodeling factor INI1/hSNF5/BAF47 is involved in activation of the colony stimulating factor 1 promoter.
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pubmed:affiliation |
Institute of Genetics and Cytology, School of Life Science, Northeast Normal University, Changchun, 130024, Jilin, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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