Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-11-9
pubmed:abstractText
Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirates classified as undeterminate by cytology. After establishing an easy processing of aspirates for galectin-3 immunodetection, a series of aspirates categorised as benign (n=63), malignant (n=17) or undeterminate (n=34) was prospectively analysed for galectin-3. Only the patients with malignant or undeterminate lesions underwent surgery. Most lesions (86%) diagnosed as malignant by cytology or after surgery were positive for galectin-3. The majority of lesions (94%) classified as benign by cytology or after surgery was negative for galectin-3. The positive and negative predictive values were 83 and 95%, respectively. When focusing on the undeterminate lesions, the sensitivity and specificity were 75 and 90%, respectively, while the positive and negative predictive values were 82 and 87%, respectively. The specificity and the positive predictive value were higher (100%) when considering the percentage of stained cells. Altogether these results show that galectin-3 constitutes a useful marker in the diagnosis of thyroid lesions classified as undeterminate by conventional cytology.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-10536372, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-10956411, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-11156213, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-11425367, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-11701669, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-11740048, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-11903601, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-12033961, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-12223276, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-14585093, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-14758078, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-15240595, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-15272279, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-15326483, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-15374939, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-15386597, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-15500653, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-15742329, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-15924608, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-15941700, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-2774778, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-8156527, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-8308013, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-8618236, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-8813152, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-9237176, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-9393748, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-9679965, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-9709908, http://linkedlifedata.com/resource/pubmed/commentcorrection/16251880-9851870
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1175-81
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Galectin-3 immunodetection in follicular thyroid neoplasms: a prospective study on fine-needle aspiration samples.
pubmed:affiliation
Laboratoire d'Histologie-Biologie Tumorale, hôpital Tenon, UPRES EA 3499, Université Pierre et Marie Curie, Paris, France.
pubmed:publicationType
Journal Article, Clinical Trial