presenilin-2 is one of the causative genes for familial Alzheimer's disease, and the apolipoprotein E epsilon4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. Polymorphism of the regulatory region of presenilin-2 has recently been reported to be associated with sporadic Alzheimer's disease in a Russian population. The purpose of this study was to determine whether Alzheimer's disease is associated with the presenilin-2 gene polymorphism and the apolipoprotein E genotype in an extended case-control study.
Department of Psychiatry and Neurology, Kobe Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, and Hyogo Institute of Aging Brain and Cognitive Disorders, Himeji Brain and Heart Center, Japan.
