Source:http://linkedlifedata.com/resource/umls/id/C0528480
MSH: Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.,NCI: Presenilin-2 (448 aa, ~50 kDa) is encoded by the human PSEN2 gene. This protein is involved in proteolytic processing.