Linked Life Data

16226033

Source:http://linkedlifedata.com/resource/pubmed/id/16226033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2005-10-28
pubmed:abstractText
Lysophosphatidic acid (LPA) is a lipid-derived G-protein-coupled receptor (GPCR) agonist that is involved in a variety of physiological and pathological processes, including cell survival, proliferation and differentiation, cytoskeletal rearrangement, cell-cell interactions, tumorigenesis and cell invasion. LPA also stimulates oocyte maturation, the preimplantation development of two- or four-cell embryos to the blastocyst stage and embryo transport in the oviduct. Recent studies revealed that targeted deletion of the LPA(3) receptor results in delayed implantation and altered embryo spacing, and significantly reduced litter size in mice. This was attributable to selective downregulation of uterine cyclooxygenase-2 (COX-2), which generates prostaglandins (PGs) E(2) and I(2). Exogenous administration of PGE(2) or the PGI(2) analogue, carba-prostacyclin, to LPA(3)-deficient female mice rescued delayed implantation but did not prevent defects in embryo spacing. These findings indicate that LPA-induced COX-2 induction has a crucial role in implantation and mammalian reproduction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1043-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
397-9
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Roles of LPA3 and COX-2 in implantation.
pubmed:affiliation
Section on Hormonal Regulation, Endocrinology & Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4510, USA. shahb@mail.nih.gov
pubmed:publicationType
Journal Article