| pubmed-article:16143608 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16143608 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:16143608 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:16143608 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16143608 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:16143608 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16143608 | pubmed:dateCreated | 2005-12-22 | lld:pubmed |
| pubmed-article:16143608 | pubmed:abstractText | Hybrids between species are often characterized by novel gene-expression patterns. A recent study on allele-specific gene expression in hybrids between species of Drosophila revealed cases in which cis- and trans-regulatory elements within species had coevolved in such a way that changes in cis-regulatory elements are compensated by changes in trans-regulatory elements. We hypothesized that such coevolution should often lead to gene misexpression in the hybrid. To test this hypothesis, we estimated allele-specific expression and overall expression levels for 31 genes in D. melanogaster, D. simulans, and their F1 hybrid. We found that 13 genes with cis-trans compensatory evolution are in fact misexpressed in the hybrid. These represent candidate genes whose dysregulation might be the consequence of coevolution of cis- and trans-regulatory elements within species. Using a mathematical model for the regulation of gene expression, we explored the conditions under which cis-trans compensatory evolution can lead to misexpression in interspecific hybrids. | lld:pubmed |
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| pubmed-article:16143608 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16143608 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16143608 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16143608 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16143608 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16143608 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:16143608 | pubmed:author | pubmed-author:ClarkAndrew... | lld:pubmed |
| pubmed-article:16143608 | pubmed:author | pubmed-author:HartlDaniel... | lld:pubmed |
| pubmed-article:16143608 | pubmed:author | pubmed-author:WittkoppPatri... | lld:pubmed |
| pubmed-article:16143608 | pubmed:author | pubmed-author:LandryChristi... | lld:pubmed |
| pubmed-article:16143608 | pubmed:author | pubmed-author:TaubesCliffor... | lld:pubmed |
| pubmed-article:16143608 | pubmed:author | pubmed-author:RanzJose MJM | lld:pubmed |
| pubmed-article:16143608 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16143608 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:16143608 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16143608 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16143608 | pubmed:pagination | 1813-22 | lld:pubmed |
| pubmed-article:16143608 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16143608 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16143608 | pubmed:articleTitle | Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. | lld:pubmed |
| pubmed-article:16143608 | pubmed:affiliation | Department of Organismic and Evolutionary Biology, The Biological laboratories, 16 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA. | lld:pubmed |
| pubmed-article:16143608 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16143608 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16143608 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16143608 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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