|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2005-12-22
|
|
pubmed:abstractText |
Hybrids between species are often characterized by novel gene-expression patterns. A recent study on allele-specific gene expression in hybrids between species of Drosophila revealed cases in which cis- and trans-regulatory elements within species had coevolved in such a way that changes in cis-regulatory elements are compensated by changes in trans-regulatory elements. We hypothesized that such coevolution should often lead to gene misexpression in the hybrid. To test this hypothesis, we estimated allele-specific expression and overall expression levels for 31 genes in D. melanogaster, D. simulans, and their F1 hybrid. We found that 13 genes with cis-trans compensatory evolution are in fact misexpressed in the hybrid. These represent candidate genes whose dysregulation might be the consequence of coevolution of cis- and trans-regulatory elements within species. Using a mathematical model for the regulation of gene expression, we explored the conditions under which cis-trans compensatory evolution can lead to misexpression in interspecific hybrids.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-10676967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-10716734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-10805527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-10931750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-10980438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-11084624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-11124901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-11341673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-11504856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-11896595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-11923494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12028779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12168619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12183620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12372246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12403824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12411608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12446780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12615008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12620064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12777501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12777520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-12831481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-1375828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-14962989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15123580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15215320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15229602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15269782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15342517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15342533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15489529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15498973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15499010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15502829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15843459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-15852004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-2124699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-2179950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-3532321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-3916710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-8369279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-8813014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-9551098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-9581503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-9593720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16143608-9973553
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0016-6731
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
171
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1813-22
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:16143608-Alleles,
pubmed-meshheading:16143608-Animals,
pubmed-meshheading:16143608-Drosophila,
pubmed-meshheading:16143608-Evolution, Molecular,
pubmed-meshheading:16143608-Gene Expression Regulation,
pubmed-meshheading:16143608-Hybridization, Genetic,
pubmed-meshheading:16143608-Models, Genetic,
pubmed-meshheading:16143608-Polymerase Chain Reaction,
pubmed-meshheading:16143608-Regulatory Elements, Transcriptional
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila.
|
|
pubmed:affiliation |
Department of Organismic and Evolutionary Biology, The Biological laboratories, 16 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
