Source:http://linkedlifedata.com/resource/pubmed/id/16115131
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2005-8-23
|
| pubmed:abstractText |
Granulocyte colony-stimulating factor (G-CSF) effectively mobilises haematopoietic stem cells to the peripheral blood. It is unclear whether the mobilisation of stem cells with lenograstim (glycosylated G-CSF) or filgrastim (non-glycosylated G-CSF) leads to a higher cell number of collected engraft able progenitor cells. Thus, we investigated harvesting efficiency of the licensed G-CSF preparations in mobilising peripheral stem cells in a randomised study. A total of 501 healthy unrelated donors, including 339 males and 162 females received either lenograstim (n = 261) or filgrastim (n = 240) at 10 microg/kg body weight (BW) per day. Aphaeresis was performed on day 5 and, if necessary, on day 6 of mobilisation. The number of CD34+ cells collected was 11.5% higher in the lenograstim group (7.19 x 10(6) vs. 6.44 x 10(6)/kg BW donor; P < 0.03). Univariate variance analysis revealed that this effect was caused by male donors: more progenitors cells per kg BW of the donor (7.73 x 10(6) vs. 6.88 x 10(6); P < 0.017) and of the recipient (10.1 x 10(6) vs. 8.88 x 10(6), P < 0.029) could be harvested. There was no significant difference in the percentage of donors in whom a second aphaeresis was required (9.6% vs. 11.6%). Lenograstim mobilises progenitor cells into the peripheral blood more effectively in males than filgrastim.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Filgrastim,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/lenograstim
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
0007-1048
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
130
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
740-6
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| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:16115131-Adult,
pubmed-meshheading:16115131-Antigens, CD34,
pubmed-meshheading:16115131-Blood Component Removal,
pubmed-meshheading:16115131-Body Weight,
pubmed-meshheading:16115131-Cell Count,
pubmed-meshheading:16115131-Confounding Factors (Epidemiology),
pubmed-meshheading:16115131-Female,
pubmed-meshheading:16115131-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:16115131-Hematopoietic Stem Cell Mobilization,
pubmed-meshheading:16115131-Humans,
pubmed-meshheading:16115131-Linear Models,
pubmed-meshheading:16115131-Male,
pubmed-meshheading:16115131-Middle Aged,
pubmed-meshheading:16115131-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:16115131-Prospective Studies,
pubmed-meshheading:16115131-Quality Control,
pubmed-meshheading:16115131-Recombinant Proteins,
pubmed-meshheading:16115131-Sex Distribution,
pubmed-meshheading:16115131-Stem Cells,
pubmed-meshheading:16115131-Tissue Donors
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Superior mobilisation of haematopoietic progenitor cells with glycosylated G-CSF in male but not female unrelated stem cell donors.
|
| pubmed:affiliation |
Institute for Transplantation Diagnostics and Cell Therapeutics, University of Düsseldorf Medical School, Düsseldorf, Germany. fischer@itz.uni-duesseldorf.de
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|