|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2005-8-25
|
|
pubmed:abstractText |
Tumor necrosis factor-alpha (TNF-alpha), an inflammatory cytokine negligibly expressed in normal muscle, is elevated in selected metabolic conditions characterized by muscle wasting and insulin resistance. Inflammation is fundamental to stroke pathogenesis. Stroke patients have gross muscular atrophy and high prevalence of diabetes and insulin resistance. Yet, no previous studies examined TNF-alpha expression in hemiparetic skeletal muscle. This study investigates whether TNF-alpha mRNA levels are elevated in paretic compared with nonparetic leg muscles of chronic ischemic stroke patients and age-matched controls.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1524-4628
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
36
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2021-3
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16109906-Aged,
pubmed-meshheading:16109906-Atrophy,
pubmed-meshheading:16109906-Case-Control Studies,
pubmed-meshheading:16109906-DNA, Complementary,
pubmed-meshheading:16109906-Female,
pubmed-meshheading:16109906-Gene Expression Regulation,
pubmed-meshheading:16109906-Humans,
pubmed-meshheading:16109906-Inflammation,
pubmed-meshheading:16109906-Leg,
pubmed-meshheading:16109906-Male,
pubmed-meshheading:16109906-Middle Aged,
pubmed-meshheading:16109906-Muscle, Skeletal,
pubmed-meshheading:16109906-RNA,
pubmed-meshheading:16109906-RNA, Messenger,
pubmed-meshheading:16109906-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16109906-Ribosomes,
pubmed-meshheading:16109906-Stroke,
pubmed-meshheading:16109906-Transcription, Genetic,
pubmed-meshheading:16109906-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Elevated tumor necrosis factor-alpha in skeletal muscle after stroke.
|
|
pubmed:affiliation |
Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. cmacko@grecc.umaryland.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|
