Linked Life Data

16102786

Source:http://linkedlifedata.com/resource/pubmed/id/16102786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2005-9-19
pubmed:abstractText
Effects on behavioral response to predator stress of competitive block of NMDA receptors with doses of .1, 1.0 and 10 mg/kg of CPP (3-(2-carboxypiperazin4-yl)propyl-l-phosphonic acid) were studied. An affect test battery assessed behavioral response to stress and employed hole board, elevated plus maze, light/dark box, social interaction, social avoidance and response to acoustic startle tests. Doses of 1-10 mg/kg of CPP administered ip 30 min prior to predator stress blocked the effects of predator stress on some but not all behaviors measured 8-9 days later. Predator stress normally reduces open arm exploration and risk assessment in the plus maze, decreases entries into the lighted arm of the light dark box and delays habituation of the acoustic startle response. CPP blocked all of these effects of predator stress. A dose of 10 mg/kg of CPP was required for all behaviors except habituation to startle. Block of effects on habituation to startle occurred at 1 and 10 mg/kg. Behaviors in which effects of predator stress were not blocked by CPP included reduction in unprotected head dips in the elevated plus maze and reduced social interaction. In addition, predator stress was without effect on social avoidance measured with the Haller test. These findings extend previous work showing NMDA receptor dependence of effects of predator stress on behavior in the elevated plus maze and on amplitude of acoustic startle response. Novel findings include NMDA receptor dependence of predator stress effects on light dark box behavior and startle habituation. Taken together, the findings add to a body of evidence showing that a syndrome of behavioral changes follows predator stress. Components of this syndrome of behavioral changes likely depend on changes in separable neural substrates initiated in part by NMDA receptors as well as by other neurochemical means.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16102786-Analysis of Variance, pubmed-meshheading:16102786-Animals, pubmed-meshheading:16102786-Avoidance Learning, pubmed-meshheading:16102786-Behavior, Animal, pubmed-meshheading:16102786-Behavioral Symptoms, pubmed-meshheading:16102786-Cats, pubmed-meshheading:16102786-Dose-Response Relationship, Drug, pubmed-meshheading:16102786-Excitatory Amino Acid Antagonists, pubmed-meshheading:16102786-Handling (Psychology), pubmed-meshheading:16102786-Interpersonal Relations, pubmed-meshheading:16102786-Male, pubmed-meshheading:16102786-Periodicity, pubmed-meshheading:16102786-Phosphonic Acids, pubmed-meshheading:16102786-Piperazines, pubmed-meshheading:16102786-Predatory Behavior, pubmed-meshheading:16102786-Random Allocation, pubmed-meshheading:16102786-Rats, pubmed-meshheading:16102786-Rats, Long-Evans, pubmed-meshheading:16102786-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:16102786-Startle Reaction, pubmed-meshheading:16102786-Stress, Psychological
pubmed:year
2005
pubmed:articleTitle
Role of NMDA receptors in the syndrome of behavioral changes produced by predator stress.
pubmed:affiliation
Department of Psychology, Memorial University, St. John's, NF, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't