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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-7-14
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pubmed:abstractText |
Recently, the in vivo pathogenic role of anti-neutrophil cytoplasm autoantibodies (ANCA) in ANCA-associated vasculitis has been challenged by Abdel-Salam et al. In their report, they observed that ANCA directed against proteinase 3 (PR3) cannot bind to their target autoantigen PR3 on circulating neutrophils (PMN). Here we present evidence that human PR3-ANCA do specifically bind to PMN that express PR3 on their membrane.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
537-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16014030-Antibodies, Antineutrophil Cytoplasmic,
pubmed-meshheading:16014030-Antibody Specificity,
pubmed-meshheading:16014030-Humans,
pubmed-meshheading:16014030-Immunoglobulin G,
pubmed-meshheading:16014030-Myeloblastin,
pubmed-meshheading:16014030-Neutrophils,
pubmed-meshheading:16014030-Protein Binding,
pubmed-meshheading:16014030-Serine Endopeptidases,
pubmed-meshheading:16014030-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16014030-Wegener Granulomatosis
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pubmed:year |
2005
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pubmed:articleTitle |
Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to neutrophils.
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pubmed:affiliation |
Department of Rheumatology and Clinical Immunology, Groningen University Medical Centre, Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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