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pubmed-article:15956925pubmed:abstractTextAn atherosclerotic abdominal aortic aneurysms (AAAA) differ from inflammatory abdominal aortic aneurysms (IAAA), which are characterized by a non specific inflammatory reaction leading to considerable aneurysmal wall thickness from the media to adventitia and retroperitoneal fibrosis in the surrounding tissue. Platelet-derived growth factor (PDGF) and its receptor have been localized to specific cell types within atherosclerotic plaques. Human connective tissue growth factor (CTGF) is a cysteine rich polypeptide that has similar structures to PDGF and has been implicated in connective tissue formation. PDGF and CTGF may play a role in the development of aneurysmal walls in both AAAA and IAAA.lld:pubmed
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pubmed-article:15956925pubmed:articleTitleThe expression of platelet-derived growth factor and connective tissue growth factor in different types of abdominal aortic aneurysms.lld:pubmed
pubmed-article:15956925pubmed:affiliationDivision of Cardiovascular Surgery, Himeji Central Hospital, Himeji, Hyogo, Japan.lld:pubmed
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