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pubmed-article:1595064pubmed:dateCreated1992-7-2lld:pubmed
pubmed-article:1595064pubmed:abstractTextThe aim of this study was to determine the influence of the nature of the perigraft tissue in the healing pattern of high-porosity polytetrafluoroethylene (PTFE) vascular grafts. Nine-centimeter long segments of unreinforced experimental high-porosity (60 microns) PTFE grafts were placed as abdominal aortic interposition in mongrel dogs. Three grafts served as controls (group A); in five dogs (group B) a 25 x 25 cm piece of devascularized omentum was wrapped around the graft. In five dogs (group C) the omentum with its own vascular supply was completely wrapped around the graft. Animals were killed 4 weeks after surgery. The percentage of thrombus-free area was 31% in group A grafts, 39% in group B grafts, and 79% in group C grafts (p less than 0.01). Scanning electron microscopy showed many confluent areas of endothelium-like cells in the midportion of group C grafts, corresponding to capillary ingrowth. Transmural endothelial migration was more evident in group C grafts. We conclude that the nature of the perigraft tissue influences transmural capillary migration and the endothelialization rate of high-porosity PTFE grafts in dogs. Agents able to increase capillary formation in the perigraft tissue might improve endothelialization of vascular grafts.lld:pubmed
pubmed-article:1595064pubmed:languageenglld:pubmed
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pubmed-article:1595064pubmed:authorpubmed-author:SchultzR DRDlld:pubmed
pubmed-article:1595064pubmed:authorpubmed-author:HunterW JWJlld:pubmed
pubmed-article:1595064pubmed:authorpubmed-author:FarinaCClld:pubmed
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pubmed-article:1595064pubmed:volume111lld:pubmed
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pubmed-article:1595064pubmed:pagination677-82lld:pubmed
pubmed-article:1595064pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:1595064pubmed:year1992lld:pubmed
pubmed-article:1595064pubmed:articleTitleHealing of high-porosity polytetrafluoroethylene arterial grafts is influenced by the nature of the surrounding tissue.lld:pubmed
pubmed-article:1595064pubmed:affiliationDepartment of Surgery and Pathology, Creighton University School of Medicine, Omaha, Neb.lld:pubmed
pubmed-article:1595064pubmed:publicationTypeJournal Articlelld:pubmed