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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1992-7-2
|
| pubmed:abstractText |
The aim of this study was to determine the influence of the nature of the perigraft tissue in the healing pattern of high-porosity polytetrafluoroethylene (PTFE) vascular grafts. Nine-centimeter long segments of unreinforced experimental high-porosity (60 microns) PTFE grafts were placed as abdominal aortic interposition in mongrel dogs. Three grafts served as controls (group A); in five dogs (group B) a 25 x 25 cm piece of devascularized omentum was wrapped around the graft. In five dogs (group C) the omentum with its own vascular supply was completely wrapped around the graft. Animals were killed 4 weeks after surgery. The percentage of thrombus-free area was 31% in group A grafts, 39% in group B grafts, and 79% in group C grafts (p less than 0.01). Scanning electron microscopy showed many confluent areas of endothelium-like cells in the midportion of group C grafts, corresponding to capillary ingrowth. Transmural endothelial migration was more evident in group C grafts. We conclude that the nature of the perigraft tissue influences transmural capillary migration and the endothelialization rate of high-porosity PTFE grafts in dogs. Agents able to increase capillary formation in the perigraft tissue might improve endothelialization of vascular grafts.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0039-6060
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
111
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
677-82
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1595064-Animals,
pubmed-meshheading:1595064-Arteries,
pubmed-meshheading:1595064-Blood Vessel Prosthesis,
pubmed-meshheading:1595064-Capillaries,
pubmed-meshheading:1595064-Dogs,
pubmed-meshheading:1595064-Endothelium, Vascular,
pubmed-meshheading:1595064-Microscopy, Electron, Scanning,
pubmed-meshheading:1595064-Polytetrafluoroethylene,
pubmed-meshheading:1595064-Vascular Patency,
pubmed-meshheading:1595064-Wound Healing
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Healing of high-porosity polytetrafluoroethylene arterial grafts is influenced by the nature of the surrounding tissue.
|
| pubmed:affiliation |
Department of Surgery and Pathology, Creighton University School of Medicine, Omaha, Neb.
|
| pubmed:publicationType |
Journal Article
|