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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0021753,
umls-concept:C0021764,
umls-concept:C0086282,
umls-concept:C0185117,
umls-concept:C0205054,
umls-concept:C0292142,
umls-concept:C0441712,
umls-concept:C0677626,
umls-concept:C0851285,
umls-concept:C0872357,
umls-concept:C1158770,
umls-concept:C1456820,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2005-5-24
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pubmed:abstractText |
Lymphotoxin-beta (LT-beta) plays an important role in inflammation and its promoter contains a functional nuclear factor-kappaB (NF-kappaB) element, rendering it a likely target of pro-inflammatory cytokines. Inflammatory cytokines play a central role in liver regeneration resulting from acute or chronic liver injury, with interleukin (IL)-6 signaling essential for liver regeneration induced by partial hepatectomy. In hepatic oval cells observed following chronic liver injury, LT-beta levels are upregulated, suggesting a link between LT-beta and liver regeneration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EGR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/KLF3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Kruppel-Like Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/LTB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B p50 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/Sp1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1478-3223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
633-46
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15910501-Animals,
pubmed-meshheading:15910501-Base Sequence,
pubmed-meshheading:15910501-Carcinoma, Hepatocellular,
pubmed-meshheading:15910501-Cell Line, Transformed,
pubmed-meshheading:15910501-Cell Line, Tumor,
pubmed-meshheading:15910501-DNA-Binding Proteins,
pubmed-meshheading:15910501-Early Growth Response Protein 1,
pubmed-meshheading:15910501-Gene Expression Regulation,
pubmed-meshheading:15910501-Hepatocytes,
pubmed-meshheading:15910501-Humans,
pubmed-meshheading:15910501-Immediate-Early Proteins,
pubmed-meshheading:15910501-Interleukin-1,
pubmed-meshheading:15910501-Interleukin-6,
pubmed-meshheading:15910501-Kruppel-Like Transcription Factors,
pubmed-meshheading:15910501-Liver Neoplasms,
pubmed-meshheading:15910501-Lymphotoxin-alpha,
pubmed-meshheading:15910501-Lymphotoxin-beta,
pubmed-meshheading:15910501-Membrane Proteins,
pubmed-meshheading:15910501-Molecular Sequence Data,
pubmed-meshheading:15910501-Mutagenesis, Site-Directed,
pubmed-meshheading:15910501-NF-kappa B,
pubmed-meshheading:15910501-NF-kappa B p50 Subunit,
pubmed-meshheading:15910501-Promoter Regions, Genetic,
pubmed-meshheading:15910501-Protein Precursors,
pubmed-meshheading:15910501-Proto-Oncogene Proteins,
pubmed-meshheading:15910501-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:15910501-Signal Transduction,
pubmed-meshheading:15910501-Sp1 Transcription Factor,
pubmed-meshheading:15910501-Transcription, Genetic,
pubmed-meshheading:15910501-Transcription Factor RelA,
pubmed-meshheading:15910501-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Hepatic expression of the tumor necrosis factor family member lymphotoxin-beta is regulated by interleukin (IL)-6 and IL-1beta: transcriptional control mechanisms in oval cells and hepatoma cell lines.
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pubmed:affiliation |
Biochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, Western Australia, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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