Source:http://linkedlifedata.com/resource/pubmed/id/15905193
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2005-8-22
|
| pubmed:abstractText |
This study was undertaken to analyze the differentiation profiles assessed by immunophenotyping in AIDS-related B-cell lymphoma (ARL) and their relation to the clinical course. Paraffin-embedded sections of 89 ARL cases during 1989 to 2004 were stained immunohistochemically with antibodies to CD3, CD10, CD20, CD38, CD138/Syndecan-1 (Syn-1), multiple myeloma-1/interferon regulatory factor-4 (MUM1/IRF4), B-cell lymphoma protein-2 (BCL-2), BCL-6, latent membrane protein-1 (LMP-1), and Ki-67. Expression of CD10 and CD20 were associated with better overall survival (OS; P = .009 and P = .04, respectively). Expression of CD20 was associated with longer disease-free survival (DFS; P = .03), whereas expression of CD138/Syn-1 was associated with shorter DFS (P = .03). OS and DFS were worse in patients with immunophenotypic profiles related to post-germinal center (GC) differentiation (BCL-6 and CD10 negative, MUM1/IRF4 and/or CD138/Syn-1 positive) when compared with GC differentiation (P = .01). When controlled for age-adjusted International Prognostic Index (IPI), prior AIDS-defining illness (ADI), and year of ARL diagnosis, a post-GC differentiation remained significantly associated with poor OS and DFS. Expression of CD10 was associated with a preserved immunocompetence, whereas CD20 was less frequent in patients developing ARL while on highly active antiretroviral therapy (P = .04). In summary, lack of CD20 or CD10 expression and a post-germinal center signature are associated with a worse prognosis in ARL.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD20,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Neprilysin,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0006-4971
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| pubmed:author |
pubmed-author:ErnestusKarenK,
pubmed-author:FatkenheuerGerdG,
pubmed-author:HoffmannChristianC,
pubmed-author:HorstHeinz-AugustHA,
pubmed-author:JanssenDirkD,
pubmed-author:OetteMarkM,
pubmed-author:ParwareschRezaR,
pubmed-author:PlettenbergAndreasA,
pubmed-author:SchraderCarstenC,
pubmed-author:StoehrAlbrechtA,
pubmed-author:TiemannMarkusM,
pubmed-author:VierbuchenMathiasM,
pubmed-author:WolfEvaE,
pubmed-author:WyenChristophC
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
106
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1762-9
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| pubmed:meshHeading |
pubmed-meshheading:15905193-Adult,
pubmed-meshheading:15905193-Aged,
pubmed-meshheading:15905193-Antigens, CD,
pubmed-meshheading:15905193-Antigens, CD20,
pubmed-meshheading:15905193-Antigens, Differentiation,
pubmed-meshheading:15905193-Disease-Free Survival,
pubmed-meshheading:15905193-Female,
pubmed-meshheading:15905193-Follow-Up Studies,
pubmed-meshheading:15905193-Germinal Center,
pubmed-meshheading:15905193-Humans,
pubmed-meshheading:15905193-Immunohistochemistry,
pubmed-meshheading:15905193-Immunophenotyping,
pubmed-meshheading:15905193-Lymphoma, AIDS-Related,
pubmed-meshheading:15905193-Male,
pubmed-meshheading:15905193-Middle Aged,
pubmed-meshheading:15905193-Neprilysin,
pubmed-meshheading:15905193-Prognosis,
pubmed-meshheading:15905193-Regression Analysis,
pubmed-meshheading:15905193-Reproducibility of Results,
pubmed-meshheading:15905193-Retrospective Studies,
pubmed-meshheading:15905193-Survival Analysis,
pubmed-meshheading:15905193-Time Factors,
pubmed-meshheading:15905193-Tumor Markers, Biological
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping.
|
| pubmed:affiliation |
Infectious Diseases Outpatient Clinic, II. Department of Medicine, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Chemnitzstrasse 33, 24116 Kiel, Germany. c.hoffmann@med2.uni-kiel.de
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| pubmed:publicationType |
Journal Article,
Clinical Trial
|