15883646

Source:http://linkedlifedata.com/resource/pubmed/id/15883646

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007595, umls-concept:C0037083, umls-concept:C0070099, umls-concept:C0174680, umls-concept:C0205263, umls-concept:C0237477, umls-concept:C1521840, umls-concept:C1710082
pubmed:issue	6
pubmed:dateCreated	2005-5-10
pubmed:abstractText	PTHrP control of the MC3T3-E1 cell cycle machinery showed that, during differentiation, PTHrP induced G1 growth arrest. Cyclin D1 was a critical mediator as a downstream effector of cAMP, PKC, and MAPK signaling, and the process was PKA-independent. The involvement of JunB has been found critical for PTHrP effects.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/DE14073, http://linkedlifedata.com/resource/pubmed/grant/DK053904, http://linkedlifedata.com/resource/pubmed/grant/P30AR46024
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8610640
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Butadienes, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase, http://linkedlifedata.com/resource/pubmed/chemical/Histones, http://linkedlifedata.com/resource/pubmed/chemical/Nitriles, http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone-Related Protein, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun, http://linkedlifedata.com/resource/pubmed/chemical/RNA, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein, http://linkedlifedata.com/resource/pubmed/chemical/U 0126
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0884-0431
pubmed:author	pubmed-author:BerryJanice EJE, pubmed-author:DattaNabanita SNS, pubmed-author:McCauleyLaurie KLK, pubmed-author:XXX
pubmed:issnType	Print
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1051-64
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:15883646-3T3 Cells, pubmed-meshheading:15883646-Animals, pubmed-meshheading:15883646-Blotting, Northern, pubmed-meshheading:15883646-Blotting, Western, pubmed-meshheading:15883646-Butadienes, pubmed-meshheading:15883646-Cell Cycle, pubmed-meshheading:15883646-Cell Differentiation, pubmed-meshheading:15883646-Cell Proliferation, pubmed-meshheading:15883646-Cell Separation, pubmed-meshheading:15883646-Cells, Cultured, pubmed-meshheading:15883646-Cyclic AMP, pubmed-meshheading:15883646-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:15883646-Cyclin D1, pubmed-meshheading:15883646-Cyclin-Dependent Kinase Inhibitor p16, pubmed-meshheading:15883646-Densitometry, pubmed-meshheading:15883646-Dose-Response Relationship, Drug, pubmed-meshheading:15883646-Down-Regulation, pubmed-meshheading:15883646-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:15883646-Enzyme Inhibitors, pubmed-meshheading:15883646-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:15883646-Flow Cytometry, pubmed-meshheading:15883646-G1 Phase, pubmed-meshheading:15883646-Gene Silencing, pubmed-meshheading:15883646-Glutathione Transferase, pubmed-meshheading:15883646-Histones, pubmed-meshheading:15883646-Immunoprecipitation, pubmed-meshheading:15883646-MAP Kinase Signaling System, pubmed-meshheading:15883646-Mice, pubmed-meshheading:15883646-Models, Biological, pubmed-meshheading:15883646-Nitriles, pubmed-meshheading:15883646-Osteoblasts, pubmed-meshheading:15883646-Parathyroid Hormone-Related Protein, pubmed-meshheading:15883646-Phosphorylation, pubmed-meshheading:15883646-Protein Kinase C, pubmed-meshheading:15883646-Proto-Oncogene Proteins c-jun, pubmed-meshheading:15883646-RNA, pubmed-meshheading:15883646-RNA, Small Interfering, pubmed-meshheading:15883646-Retinoblastoma Protein, pubmed-meshheading:15883646-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15883646-Signal Transduction, pubmed-meshheading:15883646-Time Factors, pubmed-meshheading:15883646-Up-Regulation
pubmed:year	2005
pubmed:articleTitle	PTHrP signaling targets cyclin D1 and induces osteoblastic cell growth arrest.
pubmed:affiliation	Department of Periodontics/Prevention/Geriatrics, University of Michigan, Ann Arbor, Michigan 48109-1078, USA. nsdatta@umich.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural