| pubmed-article:15790784 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15790784 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:15790784 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:15790784 | lifeskim:mentions | umls-concept:C2350332 | lld:lifeskim |
| pubmed-article:15790784 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:15790784 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15790784 | pubmed:dateCreated | 2005-6-21 | lld:pubmed |
| pubmed-article:15790784 | pubmed:abstractText | Exosomes are secreted vesicles formed in late endocytic compartments. Immature dendritic cells (DCs) secrete exosomes, which transfer functional major histocompatibility complex (MHC)-peptide complexes to other DCs. Since immature and mature DCs induce different functional T-cell responses (ie, tolerance versus priming), we asked whether DC maturation also influenced the priming abilities of their exosomes. We show that exosomes secreted by lipopolysaccharide (LPS)-treated mature DCs are 50- to 100-fold more potent to induce antigen-specific T-cell activation in vitro than exosomes from immature DCs. In vitro, exosomes from mature DCs transfer to B lymphocytes the ability to prime naive T cells. In vivo, only mature exosomes trigger effector T-cell responses, leading to fast skin graft rejection. Proteomic and biochemical analyses revealed that mature exosomes are enriched in MHC class II, B7.2, intercellular adhesion molecule 1 (ICAM-1), and bear little milk-fat globule-epidermal growth factor-factor VIII (MFG-E8) as compared with immature exosomes. Functional analysis using DC-derived exosomes from knock-out mice showed that MHC class II and ICAM-1 are required for mature exosomes to prime naive T cells, whereas B7.2 and MFG-E8 are dispensable. Therefore, changes in protein composition and priming abilities of exosomes reflect the maturation signals received by DCs. | lld:pubmed |
| pubmed-article:15790784 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15790784 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15790784 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15790784 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15790784 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15790784 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:15790784 | pubmed:author | pubmed-author:AmigorenaSeba... | lld:pubmed |
| pubmed-article:15790784 | pubmed:author | pubmed-author:RaposoGraçaG | lld:pubmed |
| pubmed-article:15790784 | pubmed:author | pubmed-author:ThéryClotilde... | lld:pubmed |
| pubmed-article:15790784 | pubmed:author | pubmed-author:SeguraElodieE | lld:pubmed |
| pubmed-article:15790784 | pubmed:author | pubmed-author:VéronPhilippe... | lld:pubmed |
| pubmed-article:15790784 | pubmed:author | pubmed-author:BatteuxFrédér... | lld:pubmed |
| pubmed-article:15790784 | pubmed:author | pubmed-author:NiccoCaroleC | lld:pubmed |
| pubmed-article:15790784 | pubmed:author | pubmed-author:LombardBérang... | lld:pubmed |
| pubmed-article:15790784 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15790784 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15790784 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:15790784 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15790784 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15790784 | pubmed:pagination | 216-23 | lld:pubmed |
| pubmed-article:15790784 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15790784 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15790784 | pubmed:articleTitle | ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. | lld:pubmed |
| pubmed-article:15790784 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale, Laboratory of Mass Spectrometry and Proteomics, Centre National de la Recherche Scientifique-Unité Mixte de Recherche, Paris, France. | lld:pubmed |
| pubmed-article:15790784 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15790784 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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